肝细胞性肝癌代谢组学研究进展  

Advances in metabonomics of hepatocellular carcinoma

作　　者：刘悦[1] 赵亮[2] 李燕[3] 朱臻宇[1] 柴逸峰[1] 

机构地区：[1]第二军医大学药学院药物分析教研室,上海200433 [2]第二军医大学附属东方肝胆外科医院药材科,上海200438 [3]中国人民解放军总后勤部郑常庄干部休养所,北京100141

出　　处：《药学实践杂志》2013年第2期81-85,共5页Journal of Pharmaceutical Practice

摘　　要：肝细胞性肝癌(HCC)是最常见的、发病率和死亡率较高的恶性肿瘤之一,严重危害了人类的健康。代谢组学能够将高通量、高分辨率的分析技术与生物信息学相整合,对生物代谢层面进行研究,为寻找早期诊断肝细胞性肝癌的生物标志物、探索HCC发生的机制提供独特的视角。本文对近年来肝细胞性肝癌代谢组学研究进展进行综述,为进一步深入研究提供参考。Hepatocellular carcinoma （HCC） was one of the most common malignancies with high incidence and mortality which threatened human health. Integrating analytical technology of high throughput and high resolution with hioinformatics, metabo- nomics could investigate the organism on the level of metabolism, provide a unique insight into searching biomarkers for early diagnosis of HCC and exploring the mechanism of HCC . The advances of metabonomics studies on HCC in the recent years were reviewed in this paper which could provide the reference for further research.

关 键 词：肝细胞性肝癌 代谢组学 生物标志物 研究进展 

分 类 号：R735.7[医药卫生—肿瘤]