妇科肿瘤患者尿路感染大肠埃希菌的耐药性分析  

Resistance of E.coli isolated from urinary tract infection in gynecological cancer patients

作　　者：郭凤丽[1,2] 翟丽[1,2] 杨丽[1,2] 

机构地区：[1]昆明医科大学第三附属医院 [2]云南省肿瘤医院,昆明650118

出　　处：《检验医学与临床》2013年第8期917-918,共2页Laboratory Medicine and Clinic

基　　金：云南省科技厅-昆明医学院联合专项项目(2011C146)

摘　　要：目的了解妇科肿瘤患者尿路感染大肠埃希菌的耐药性,给临床合理用药提供参考。方法对2006年1月至2010年12月妇科肿瘤患者尿路感染尿培养分离出的110株大肠埃希菌耐药性进行统计分析,用纸片扩散法表型确证试验检测ESBLs。结果 110株大肠埃希菌产ESBLs率86.36%,对氨苄西林的耐药率达96.24%;对喹诺酮类耐药达84.00%以上;头孢1～4代耐药率均高于86.36%;庆大霉素69.09%。头孢西丁、哌拉西林/他唑巴坦、阿米卡星、磷霉素及呋喃妥因耐药率较低,小于或等于19.62%,亚胺培南耐药率为0.00%。结论妇科肿瘤患者尿路感染大肠埃希菌产ESBLs呈逐年增高趋势,对多种抗菌药物具有高度耐药性。头孢西丁、哌拉西林/他唑吧坦、磷霉素及呋喃妥因耐药率较低,可用于妇科肿瘤患者泌尿道感染早期经验用药。Objective To study the trend of antibiotic resistance in gynecological cancer patients with urinary tract infection caused by Escherichia coli （E. coli）, and provide some reference for reasonable treatment. Methods Antibiotic resistance was analyzed in 110 E. coli strains isolated from gynecological cancer patients with u- rinary tract infection from January 2006 to December 2010. ESBLs in urine samples were detected by disk diffusion phenotypie confirmatory test. Results The rate of ESBLs producing E. coli was 86.36 %. The resistance rate to am- pieillin was 96.24%, to quinolones was more than 84.0%, to lst-4th generation cephalosporins were more than 86. 36%, and to gentamicin was 69.09Resistance of E. coli isolated from urinary tract infection in gynecological cancer patients. Rates of antibiotic resistance to cefoxitin, piperacillin/cilostazol, amika- cin, fosfomycin and nitrofurantoin were all lower than 19.62%, the resistance rate to imipenem was 0.00%. Conclu- sion In gynecological cancer patients with urinary tract infection, there is a significant increasing trend in ESBLs- producing E. coli, which has highly resistance to a variety of antimicrobial drugs. For cefoxitin, piperacillin/cilostazol, fosfomycin and nitrofurantoin have lower resistance rate, they can be used as an empiric treatment in early gyne- cological cancer patients with urinary tract infection.

关 键 词：妇科肿瘤患者 尿路感染 大肠埃希菌 耐药性 

分 类 号：R737.305[医药卫生—肿瘤]