精神分裂症血清免疫球蛋白的糖链分析  

Study on saccharide chains of serum immunoglobulin in patients with schizophrenia

作　　者：郭静[1] 邱锦云[1] 郭航[1] 冯方波[1] 

机构地区：[1]中国人民解放军第二六一医院,北京100094

出　　处：《国际检验医学杂志》2013年第7期795-795,797,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨精神分裂症患者血清免疫球蛋白(IgG、IgM、IgA)寡糖链中糖组分的定量变化及与血清总免疫球蛋白的相关性。方法采用毡毛小脆柄菇凝集素(PVL)亲和夹心ELISA法检测精神分裂症患者和对照组血清免疫球蛋白糖链构成,及与血清免疫球蛋白总量进行相关比较分析。结果精神分裂症患者血清PVL-IgG水平明显高于对照组(P<0.01)。精神分裂症患者血清PVL-IgA与总IgA呈弱正相关外(r=0.1945),其他指标无论患者或对照组均无明显相关性。结论精神分裂症血清免疫球蛋白的糖基化异常修饰主要发生在IgG组分,但IgG糖基化程度与血清IgG总量无明显相关性。Objective To investigate the correlation between sugar changes in oligosaccharide chains derived from immunoglobu- lin （IgG,IgM,IgA） and total serum immunoglobulin level in schizophrenic patients. Methods Serum Paton-Valentine Leukoeidin （PVL）-Ig level in schizophrenic patients were detected by PVL binding ELISA. Further, the correlation between the serum level of PVL-Ig and total Ig were determined by linear regression analysis. Results Schizophrenia patients serum PVL-IgG was significant- ly higher than the control group（P^0.01）. Schizophrenia patients serum PVL-IgA and total IgA showed a weak positive correla- tion（r：0. 194 5） ,the other indexes had no obvious correlation between either patients or controls. Conclusion Abnormal glycosy- lation of serum Ig in schizophrenic patients mainly occurred in IgG. In addition, there was no significant correlation between the de- gree of glycosylation and total serum IgG level.

关 键 词：精神分裂症 酶联免疫吸附测定 免疫球蛋白类 

分 类 号：R749.3[医药卫生—神经病学与精神病学]