老年子宫内膜癌组织中ER、PR的表达及临床意义  

Expression of ER,PR and clinical significance in elderly endometrial carcinoma patients

作　　者：徐燕颖[1] 尹利荣[1] 杨维娜[1] 王莉[1] 

机构地区：[1]天津医科大学第二医院妇科,天津300211

出　　处：《中国老年学杂志》2013年第8期1739-1740,共2页Chinese Journal of Gerontology

基　　金：国家自然科学基金青年科学基金项目(No.81102613)

摘　　要：目的探讨老年子宫内膜癌雌激素受体(ER)、孕激素受体(PR)的表达以及临床意义。方法选取老年子宫内膜癌患者43例(实验组),32例正常子宫内膜组织(对照组),采用免疫组化法检测两组人群中ER、PR的表达水平,结合临床病理资料进行相关分析。结果 (1)老年子宫内膜癌组织中ER和PR表达较对照组低(P<0.05)。(2)在老年子宫内膜癌组织中,随临床病理分期、组织学分级的升高和肌层浸润的加深,ER、PR的表达水平下降,差异均有统计学意义(P<0.05)。结论 ER、PR的检测反映了子宫内膜癌的生物学行为和预后,有助于指导其治疗。Objective To study the positive expression rate and clinical significance of estrogen receptor（ER） and progesterone re-ceptor （PR） in old endometrial carcinoma patients. Methods 43 cases with endometrial carcinoma were selected in experimental group, and 32 cases of normal endometrium organization were in control group. ER, PR of endometrial carcinoma specimen were measured by immu- nohistochemical. Results The expressions of ER and PR of experimental group were lower in control group （P 〈 0. 05）. In the elderly en- dometrial carcinoma tissues, the expressions quantity of ER and PR were decreased, along with the clinical pathologic stage, histological grade rising and muscle layer infiltrating deepen, and the differences were statistically significant （ P 〈 0. 05 ）. Conclusions To a certain degree, the detection of ER, PR could react the biologic behaviors and prognosis of carcinoma, and help to guide treatment.

关 键 词：子宫内膜癌 雌激素受体 孕激素受体 

分 类 号：R737[医药卫生—肿瘤]