中国东北地区遗传性非息肉病性结直肠癌家系多原发癌的特点分析  

Multiple primary carcinoma in Chinese hereditary nonpolyposis colorectal cancer patients in Northeast China

作　　者：唐元新[1] 李晓霞[1] 孙公平[1] 李鑫 赵萌[1] 闫一飞[1] 孟金[1] 

机构地区：[1]中国医科大学附属第四医院胃肠外科,沈阳110032

出　　处：《中华普通外科杂志》2013年第4期253-255,共3页Chinese Journal of General Surgery

基　　金：辽宁省教育厅高等学校科研基金资助项目（2008781）;2011年辽宁省自然科学基金资助项目（201102281）

摘　　要：目的探讨东北地区遗传性非息肉病性结直肠癌（HNPCC）家系多原发癌的特点。方法对登记的85个严格符合Amsterdam标准Ⅱ的HNPCC家系共509例患者的多原发癌的特点进行回顾性分析。结果在85个HNPCC家系中，共25个家系55例患者发生多原发癌，其中17个家系45例患者发生异时性多原发癌，12个家系16例患者发生同时性多原发癌，4个家系6例患者合并异时性和同时性多原发癌。结论中国东北地区HNPCC家系中多原发癌患者明显增多，最常见的为右半结肠癌、直肠癌、乙状结肠癌、横结肠癌、左半结肠癌、子宫内膜癌等。Objective To investigate the familial incidence of multiple primary carcinoma in Chinese hereditary nonpolyposis colorectal cancer patients （HNPCC） in Northeast China. Methods By family line investigation, multiple primary carcinoma（ MPC ） spectrum＇s characteristics of 509 patients in 85 families registered in strict conformity with the HNPCC Amsterdam criteria I1 were analyzed retrospectively. Results Of the 85 HNPCC families, muhiple primary carcinoma developed in 55 patients in 25 families, among them 45 patients had metachronous carcinoma in 17 families, 16 patients had synchronous carcinoma occurred in 12 families,6 patients with both synchronous carcinoma and metachronous carcinoma in 4 families. Conclusions Multiple primary carcinoma developed in significantly high incidence in Northeast China in Chinese hereditary nonpolyposis eolorectal cancer patients, the most common MPC are colorectal cancer and endometrial cancer.

关 键 词：结直肠肿瘤 遗传性非息肉性 肿瘤 多原发性 家庭 

分 类 号：R735.34[医药卫生—肿瘤]