精神分裂症患者探究性眼球轨迹运动与表皮生长因子4(ERBB4)基因多态性的关联  

Association of ERBB4 polymorphisms with EEM abnormality in schizophrenia patients of Chinese Han population

作　　者：李梓萌[1] 潘超[1] 卢天兰[1] 阮燕燕[1] 朱日升[1] 王力芳[1] 阎浩[1] 岳伟华[1] 张岱[1] 

机构地区：[1]北京大学精神卫生研究所,卫生部精神卫生学重点实验室(北京大学),北京100191

出　　处：《中国神经精神疾病杂志》2013年第4期208-212,共5页Chinese Journal of Nervous and Mental Diseases

摘　　要：目的研究精神分裂症患者探究性眼球轨迹运动(exploratory eye movement,EEM)与表皮生长因子4(V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4,ERBB4)基因多态性的关联。方法对139例精神分裂症患者分别进行EEM检查及全基因组单核苷酸多态性(single nucleotide polymorphism,SNP)位点芯片检测,对EEM与ERBB4基因447个SNPs进行数量性状位点关联分析(quantitative trait locus,QTL)。结果 ERBB4基因的7个SNPs位点(rs12619728,rs17737553,rs1344906,rs10168717,rs10165449,rs10932380,rs7594456)与精神分裂症患者EEM的关联有统计学意义(P<0.05),经多重检验阳性发现错误率(positive falsediscovery rate,pFDR)校正仍有统计学意义(q<0.2)。结论ERBB4基因可能是精神分裂症探究性眼球轨迹运动异常的易感基因之一。Objectives To explore the association of V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 （ERBB4） polymorphisms with the exploratory eye movement （EEM） abnormality in schizophrenia patients of Chinese Han population. Methods One hundred and thirty-nine schizophrenia patients were examined by both the EEM and the Illumina HumanHap610 SNP Beadarray. Using the quantitative trait locus （QTL） analysis, we explored the association of 447 single neucleotide polymorphisms （SNPs） with EEM characteristics, the responsive search score （RSS） and cognitive search score （CSS）, respectively. Results Seven SNPs at ERBB4 gene （rs12619728, rs17737553, rs1344906, rs10168717, rs10165449, rs10932380, rs7594456） were associated with both RSS and CSS of EEM （P〈 0.05）. All of the above mentioned 7 SNPs remained significant after the positive false discovery rate （pFDR） multiple test correction （q〈0.2）. Conclusions The ERBB4 polymorphisms might be one of the susceptible genes of EEM abnormality in schizophrenia.

关 键 词：精神分裂症 探究性眼球轨迹运动 ERBB4 基因 单核苷酸多态性 

分 类 号：R749.3[医药卫生—神经病学与精神病学]