肺腺癌组织中OCT4表达与患者临床指标及预后的相关性  

Correlations between OCT4 Expression and Clinicopathological Factors and Prognosis of Patients with Lung Adenocarcinoma

作　　者：张雪艳[1] 王慧敏[1] 金波[1] 董强刚[2] 黄进肃[1] 韩宝惠[1] 

机构地区：[1]上海交通大学胸科医院呼吸内科,上海200030 [2]上海交通大学肿瘤研究所,上海200030

出　　处：《中国肺癌杂志》2013年第4期197-202,共6页Chinese Journal of Lung Cancer

摘　　要：背景与目的肺腺癌发病率不断升高,而OCT4是调控干细胞自我更新的关键基因,在癌干细胞的增殖分化过程中起重要调节作用。本研究目的为检测肺腺癌组织中OCT4表达,并分析其与肺腺癌患者转移、化疗疗效及预后的相关性。方法采用免疫荧光方法检测肺腺癌组织OCT4表达。卡方检验OCT4表达与临床病理指标的关系,Kaplan-Meier生存曲线计算生存率,采用Cox分析评估各指标与患者生存之间的关系。结果 126例肺腺癌组织中,91例可观察到OCT4阳性细胞。OCT4表达与肺腺癌患者转移及化疗耐药密切相关,且与患者无病生存期和生存期呈明显负相关。结论 OCT4表达与肺腺癌患者的转移及化疗耐药相关,提示预后不良。Background and objective In recent years, cases of lung adenocarcinoma morbidity have consistently grown. OCT4 is the key gene that controls the automatic renewal of stem cells, and regulates the proliferation and differentiation of cancer stem cells. The aim of this study is to detect OCT4 expression in lung adenocarcinoma tissues, and to evaluate its relevance in the metastasis, chemotherapeutic effect, and prognosis in lung adenocarcinoma patients. Methods Immunofluo- rescence method was employed to detect OCT4 expression in lung adenocarcinoma tissues. The relationship between OCT4 expression and clinical pathological indicators is examined through chi-square test. Moreover, the survival rate is calculated through the Kaplan-Meier survivorship curve. Finall）5 the relevance between the indicators and patient survival is estimated using Cox analysis. Results Among the 126 tissue samples of lung adenocarcinoma, 91 showed OCT4 positive cells. OCT4 expression is closely related to metastasis and chemoresistance in lung adenocarcinoma patients, and negatively corresponds to the patients＇ disease-free survival and survival periods. Conclusion OCT4 expression is related to metastasis and chemoresis- tance in lung adenocarcinoma patients, and thus indicates poor prognosis.

关 键 词：肺肿瘤 OCT4 预后 

分 类 号：R734.2[医药卫生—肿瘤]