0．1％溴芬酸钠水合物滴眼液在准分子激光原位角膜磨镶术后的临床疗效观察  

The clinical efficacy of 0. 1% bromfenac sodium hydrate ophthalmic solution after excimer laser in situ keratomileusis

作　　者：许艳[1] 赵旭[1] 张丰菊[1] 王萌萌[1] 郭宁[1] 郑燕[1] 柳静[1] 张秋露[1] 

机构地区：[1]首都医科大学附属北京同仁医院北京同仁眼科中心北京市眼科学与视觉科学重点实验室,100730

出　　处：《中华眼科杂志》2013年第4期320-326,共7页Chinese Journal of Ophthalmology

摘　　要：目的探讨近视散光眼行前弹力层下准分子激光原位角膜磨镶术（SBK）后应用0．1％溴芬酸钠水合物滴眼液的疗效及安全性。方法采用病例对照研究，中低度近视眼患者（～6．00D≤等效球镜〈-2．00D）试验组和对照组分别为17例（32只眼）和20例（40只眼），高度近视眼患者（-11．00D≤等效球镜〈-6．00D）试验组和对照组分别为22例（42只眼）和15例（26只眼）。试验组SBK术后第1天开始使用0．1％溴芬酸钠水合物滴眼液，中低度近视眼患者持续10d，高度近视眼患者持续14d；对照组术后第1天开始使用0．1％氟米龙滴眼液，持续16d。术后不同时间分别对患者进行裸眼视力、电脑验光、眼压和角膜地形图检查，术后每次随访记录患者眼部症状及相关并发症。计量资料采用独立样本t检验，等级资料采用秩和检验进行统计学分析。结果中低度近视眼患者术后1个月、3个月眼压均值试验组分别为（7．84±1．35）和（8．13±1．75）mmHg（1mmHg=0．133kPa），对照组分别为（9．37±1．28）和（9．47±1．58）mmHg，差异均有统计学意义（t=-3．244，-3．336；P〈0．05）；角膜曲率K2均值试验组分别为（38．66±1．68）和（38．754-1．45）D，对照组分别为（39．56±1．58）和（39．51±1．50）D，试验组均低于对照组，差异具有统计学意义（t=-2．299，-2．112；P〈0．05）；术后1d、7d、1个月、3个月、6个月两组间平均裸眼视力（t=-1．240，-1．917，-0．596，-1．394，-0．329）、等效球镜（t=0．054，0．222，0．936，-0．141，0．336）和术后1、3、6个月平均角膜曲率K1（t=-1．695，-1．492，-0．438）和散光CY（t=0．879，0．733，0．553）及术后6个月平均眼压（t=-1．225）、角膜曲率K2（t=-0．727）差异均无统计学意义（P〉0．05）。高度近视患者术后3个月裸眼视力均值试验组和对照组分别为5．14±0．06、5�Objective To investigate the clinical efficacy and salty of 0. 1% bromfenae sodium hydrate ophthalmic solution in myopia and astigmatism eyes after sub-Bowman keratomileusis （SBK） Methods A case control study. Number of patients with low to moderate myopia （ - 6. 00 D ≤spherical equivalent 〈 -2. 00 D） in the test and control groups was 17 cases （32 eyes） and 20 cases （40 eyes） , respectively. Number of patients with high myopia （ - 11.00 D ≤spherical equivalent 〈 - 6. 00 D） in the test and control groups was 22 cases （42 eyes） and 15 cases （26 eyes） respectively. The first day after SBK, 0. 1% bromfenac sodium hydrate eye drops was administrated 2 times/day in patients in the test group and continued for 10 and 14 days in low and high myopia, respectively. In the control group, 0. 1% fluorometholone eye drops was used 4 times/day, then reduced gradually and continuously for 16 days.Visual acuity, computer refraction, intraocular pressure （IOP） and corneal topography examination were conducted at different postoperative period. Symptoms and related complications were recorded. Ranked data were statistically analyzed using the Wilcoxon rank sum test and quantitative data were analyzed using independent samples t-test. Results For low to moderate myopic patients, average postoperative IOP and corneal curvature K2 after one and three months in the test group were （7.84±1.35） and （8. 13±1.75） mm Hg（ 1 mm Hg = 0. 133 kPa）, and （38.66±1.68） and （38.75±1.45 ） D, respectively; in the control group, these parameters were （9.37±1.28） and （9.47±1.58） mm Hg and （39.56±1.58）, and （39. 51±1.50） D, respectively. All of these data in the test group were lower than those in the control group, the differences were statistically significant （t = - 2.299, -2. 112, P 〈0.05）. There were no significant differences （ P 〈 0. 05 ） in postoperative uncorrected visual acuity, spherical equivalent, corneal curvature K1, astigmatism CY, IOP （ afte

关 键 词：二苯甲酮类 溴化苯类 眼药水 氟米龙 角膜磨镶术 激光原位 激光准分子 治疗结果 

分 类 号：R779.63[医药卫生—眼科]