0．004％曲伏前列素与2％卡替洛尔对原发性闭角型青光眼术后高眼压的降眼压作用  

Effect of 0. 004 % travoprost and 2 % carteolol on intraocular pressure in patients with ocular hypertension after laser peripheral iridotomy or trabeculectomy in primary angle-closure glaucoma

作　　者：姚宝群[1] 庞玉英[1] 李祎馨[1] 

机构地区：[1]天津医科大学总医院眼科,300052

出　　处：《中华眼科杂志》2013年第4期340-344,共5页Chinese Journal of Ophthalmology

摘　　要：目的比较0．004％曲伏前列素与2％卡替洛尔治疗原发性闭角型青光眼激光周边虹膜切除术（LPI）或小梁切除术后高眼压的临床效果。方法对照研究。将原发性闭角型青光眼行LPI或小梁切除术后眼压〉21mmHg（1mmHg=0．133kPa）的52例（52只眼）患者，分为曲伏前列素组和卡替洛尔组。分别给予0．004％曲伏前列素（每晚1次）或2％卡替洛尔（每天2次）眼液治疗。两组患者用药前后眼压、用药前后眼压差及用药后眼压下降百分率的比较均采用t检验；用药前后眼压差和用药后眼压下降百分率与前房角开放程度的关系采用Spearman相关分析法。结果曲伏前列素组患者24例（24只眼），用药前眼压（24．67±3．08）mmHg，用药后眼压（18．58±2．71）mmHg，用药前后眼压差异有统计学意义（t=5．130，P〈0．05）；卡替洛尔组28例（28只眼），用药前眼压（23．57±1．60）mmHg，用药后眼压（19．57±1．60）mmHg，用药前后眼压差异有统计学意义（t=6．600，P〈0．05）。两组患者间用药前后眼压差（t=2．533）和用药后眼压下降百分率（t=2．532）差异均有统计学意义（P〈0．05）。两组患者的用药前后眼压差（r=0．145，0．090）和用药后眼压下降百分率（r=0．009，0．183）均与前房角开放程度无关（P〉0．05）。结论0．004％曲伏前列素和2％卡替洛尔对原发性闭角型青光眼术后高眼压均有降眼压效果，0．004％曲伏前列素的降眼压效果优于2％卡替洛尔。Objective To compare the intraocular pressure （IOP） lowering effect of 0. 004% travoprost and 2% carteolol in patients with ocular hypertension （OHT） after laser peripheral iridotomy （LPI） or trabeculectomy in primary angle-closure glaucoma （PACG）. Methods Clinical case control trial. 52 consecutive PACG patients （52 eyes） with IOP 〉 21 mm Hg（1 mm Hg =0. 133 kPa）after LPI or trabeculectomy were enrolled. 24 patients received topical application of 0. 004% travoprost （once daily） and 28 received 2% carteolol（twice daily）. IOP lowering effect of travoprost and carteolol before and after treatment was measured by Goldmann tonometer and compared using t-test. The relationship of IOP lowering effect and the degree of angle open was performed by gonioscope and analyzed using Spearman rank correlation. Results Compared with pre- treatment, the IOP was significantly reduced in 24 patients （24 eyes） in 0. 004% travoprost group [ pre-treatment： （24. 67±3.08）mm Hg, post-treatment： （ 18. 58±2.71 ） mm Hg;t = 6. 600,P 〈 0.05 ], while significantly reduced in 28 patients （28 eyes） received 2% carteolol [ pre-treatment ： （23.57±1.60） mm Hg, post-treatment ： （ 19. 57±1.60） mm Hg ; t = 5. 130, P 〈 0.05 ]. 0. 004% travoprost group is more significant in both quantity and percentage of IOP lowering than 2% carteolol（t =2. 533,2. 532;P 〈0. 05）. There was no correlation between the IOP lowering effect and the degree of angle open in both groups （0. 004% travoprost r=0. 145,0. 009 ;P 〉0. 05; 2% carteolol r = 0. 090,0. 183, P 〉 0. 05 ）. Conclusions Both of 0. 004% travoprost and 2% carteolol reduce IOP in patients with OHT after LPI or trabeculectomy in PACG. 0. 004% travoprost is more effective than 2% carteolol in IOP lowering. However, the decrease of IOP is not acted through the alteration of anterior chamber angle in both study groups.

关 键 词：青光眼 闭角型 高眼压 氯前列醇 卡替洛尔 

分 类 号：R779.6[医药卫生—眼科]