先天性外中耳畸形基因学研究进展  

Advances in genetics of congenital malformation of external and middle ear

作　　者：王大勇[1] 王秋菊[1] 

机构地区：[1]解放军总医院耳鼻咽喉头颈外科耳内科,北京100853

出　　处：《临床耳鼻咽喉头颈外科杂志》2013年第9期498-504,共7页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：国家自然基金重点项目(No:30830104);国家自然基金重大国际合作项目(No:81120108009);解放军总医院博士研究生创新性科研项目(No:11BCZ03)联合资助

摘　　要：先天性外中耳畸形是一种耳鼻咽喉科常见疾病,在整个头面部先天性畸形中仅次于唇腭裂而位居第二。外耳与中耳的畸形可以单独发生,也可以作为全身性综合征序列征状在耳部的重要表现。近年来随着基因学研究的飞速发展和新技术的应用,针对先天性外中耳畸形致病基因的分子机制的研究日益引起国内外学者的关注。Summary Congenital malformation of external and middle ear is a common disease in ENT department, and the incidence of this disease is second only to cleft lip and palate in the whole congenital malformations of the head and face. The external and middle ear malformations may occur separately, or as an important ear symptom of the systemic syndrome. We systematically review and analysis the genetic research progress of congenital malforma- tion of external and middle ear, which would be helpful to understand the mechanism of external and middle ear development, and to provide clues for the further discovery of new virulence genes.

关 键 词：先天性畸形 外耳 中耳 基因 

分 类 号：R764.7[医药卫生—耳鼻咽喉科]