CD44v5及CD44v7在口腔鳞状细胞癌组织中的表达及意义  

Expression of CD44v5 and CD44v7 in oral squamous cell carcinomas and its significance

作　　者：赵莉[1,2] 穆森[1,2] 齐迹[1,2] 谢晓华[1,2] 彭旭霞[1,2] 孙佳凝[1,2] 张瑞敏[1,2] 

机构地区：[1]哈尔滨医科大学附属第二医院牙周黏膜科,哈尔滨150086 [2]哈尔滨市第四医院口腔科,哈尔滨150086

出　　处：《口腔医学》2013年第4期221-224,共4页Stomatology

基　　金：黑龙江省自然科学基金项目(D200853)

摘　　要：目的探讨细胞黏附分子CD44v5及CD44v7在口腔鳞状细胞癌(OSCC)中的表达及意义。方法用SP免疫组化方法检测CD44v5及CD44v7在43例OSCC组织和13例转移淋巴结中的表达。结果在13例OSCC转移淋巴结病例中,其对应的原发灶CD44v5表达高于转移灶(淋巴结),且差异有统计学意义(P<0.05);CD44v7在无淋巴结转移的原发灶中的表达高于有淋巴结转移的原发灶中的表达,且差异有统计学意义(P<0.05)。43例原发灶病例中,CD44v5在有、无淋巴结转移的原发灶中的表达,CD44v7在原发灶、转移灶中的表达差异均无统计学意义(P>0.05)。结论 CD44v5及CD44v7可能与口腔鳞状细胞癌的转移相关。Objective To investigate the expression of cell adhesion molecules CD44v5 and CD44v7 and their significance in oral squamous cell carcinoma（OSCC）. Methods Specimens from 43 cases of OSCC and 13 cases of metastatic lymph nodes were used to detect the expression of CD44v5 and CD44v7 by immunohistochemical SP method. Results As to 13 cases which had lymph nodes ,the expression level of CD44v5 was much higher in the primary loci than that in the metastases（lymph nodes） ,and there was statistial sig- nificance （ P 〈 0.05 ） ; the expression level of CIM4v7 was much higher in the primary loci without metastatic lymph node than that with metastatic lymph nodes, and there was statistial significance （ P 〈 0.05 ）. In the 43 cases of primary loci, no significant difference was observed in the expression of CD44v5 between 0SCC with and without metastatic lymph nodes ; there was no statistically significant difference in the expression of CD44v7 in the metastases and primary foci（ P 〉 0.05 ）. Conclusions CD44v5 and CD44v7 may be re- lated to metastasis in OSCC.

关 键 词：CD44V5 CD44v7 口腔鳞状细胞癌 转移 

分 类 号：R739.85[医药卫生—肿瘤]