生物膜在犬上颌窦提升黏膜穿孔中的作用  

Effect of biomembrane in maxillary sinus augmentation and mucosa perforation in dogs

作　　者：赵阳[1] 文勇[1] 林庆杰[1] 梁晋[1] 徐欣[1] 

机构地区：[1]山东大学口腔医院种植中心,山东省口腔生物医学重点实验室,济南250012

出　　处：《口腔医学》2013年第4期225-228,共4页Stomatology

基　　金：山东省自然基金(Y2008C107)

摘　　要：目的探究上颌窦提升术并发黏膜穿孔时,生物膜应用与否的相关影响。方法健康成年杂种犬3只,选取6个种植位点。随机分2组:对照组:建立上颌窦窦底黏膜穿通模型,黏膜穿孔直径为5 mm,同期植入种植体,植入自体骨+人工骨粉(羟基磷灰石)。实验组:模型建立同对照组,于窦底黏膜穿孔处与种植体之间覆盖生物胶原膜。术后1、3个月分别拍摄CT片。3个月后,处死动物获取标本,观察种植体骨结合情况、窦底黏膜愈合情况、以及种植体突入上颌窦腔内长度的变化。结果对照组有1颗种植体发生脱落,上颌窦腔内见有大量脓液溢出,其余5颗种植体均形成良好的骨结合。3个月时实验组与对照组种植体顶端暴露长度均增加,2组统计学差异(P>0.05)。上颌窦窦底黏膜肉眼观察下愈合良好,HE染色发现实验组与对照组均有窦底黏膜黏膜下层增厚,黏膜上皮纤毛细胞脱落。结论本实验中,上颌窦提升并发窦底黏膜穿孔应用生物膜对于骨粉的保存和转化没有明显的积极作用。Objective To explore the effect whether biomembrane was applied or not in maxillary sinus augmentation together with mucosa perforation. Methods 6 sites for implants were chosen in 3 health adult mongrel dogs and were randomly divided into 2 groups. In the control group, models with mucosa perforation at the maxillary sinus floor were established, and the diameter of the muco- sa perforation was 5mm. Implants were implanted synchronously. Autogenous bone and artificial bone particles （hydroxyapatite） were also implanted. In the experimental group, models were extablished in the same way. Biological collagen membrane was used to cover the area between sinus floor perforation site and implants. CT photos were taken 1 month and 3 months after the operation. 3 months later, the animals were sacrificed. Observe the osseointegration of implants, mucosa healing at sinus floor, and changes in lengths of implants that protruded into maxillary sinus cavity. Results 1 implant fell off in control group, and a lot of sanies overflowed from maxillary si- nus cavity. The rest 5 implants were good in osseointegration. 3 months later, the lengths of the implant exposed increased both in the ex- perimental group and control group, but there was no significant difference between the two groups （ P 〉 0.05 ）. Mucosa at maxillary si- nus floor healed well under macroscopic observation. HE staining showed that submucosa at sinus floor in both groups thickened, and the detachment of mucosal epitheliumciliated cells appeared. Conclusions In this experiment,when mucosa perforation occurred at maxil- lary sinus floor in maxillary sinus augmentation,biological membrane had no obvious positive effect on the preservation and osteogenesis of artificial bone.

关 键 词：上颌窦提升术 黏膜穿孔 胶原膜 人工骨粉 自体骨 

分 类 号：R782.13[医药卫生—口腔医学]