氟离子导入对早期釉质龋再矿化效果的体外研究  

In vitro study of the remineralization effect of fluoride iontophoresis on incipient enamel caries

作　　者：冯颢[1,2] 陈亚明[1,2] 夏露[1,2] 嵇颖辰[3] 郑春雷[4] 

机构地区：[1]南京医科大学口腔研究所 [2]南京医科大学附属口腔医院综合科,南京210029 [3]南京医科大学附属淮安第一医院口腔科,淮安223300 [4]南京医科大学康达总公司,南京210029

出　　处：《口腔医学》2013年第4期232-235,共4页Stomatology

基　　金：江苏高校高新技术产业发展项目(JH03-026);江苏高校优势学科建设工程资助项目(2011-137)

摘　　要：目的研究氟离子导入法对早期釉质龋的再矿化效果。方法早期人工釉质龋模型样本经7 d pH循环及2 d再矿化处理,于扫描电镜(SEM)和激光共聚焦显微镜(CLSM)下摄片分析。结果 SEM图片示对照组呈粗糙酸蚀状釉质表面,1.23%酸性氟磷酸盐(APF)凝胶组及氟离子导入(FI)组釉质表面相对平整;CLSM图片分析示APF与FI组病损深度(H)分别为(40.51±4.26)、(41.90±6.83)μm,荧光面积(A)分别为(38 230.87±2 704.43)、(43 407.27±4 666.09)μm2,较对照组显著减小(PH,A<0.001),但2组间无统计学差异(PH=0.912,PA=0.679)。结论氟离子导入可有效促进早期釉质龋再矿化,且效果与1.23%酸性氟磷酸盐凝胶无异。Objective To evaluate the remineralization effect of incipient enamel caries after treated with fluoride iontophresis. Meth- ods All specimens of artificial incipient enamel caries were subjected to a pH-cycling process for 7 days and a remineralizing process for 2 days. Different groups were examined with scanning electron microscopy （SEM） and confocal laser scanning microscopy （CLSM）. Results Micrographs of SEM showed a rough etching enamel surface in the control group, while those in 1.23% APF gel group and FI group showed relatively homogeneous surfaces. Fluorescence lesion area（A） and lesion depth（H） were significantly less （Pn,A 〈0.001） in APF gel group [ （38 230.87 ±2 704.43）μm2, （40. 51 ±4. 26） μm] and FI group [ （43 407.27 ±4 666.09） μm2, （41.90 ±6.83 ） μm] than those in control group, although no statistical differences could be detected between the two treatment groups（ PM = 0.912 ,PA = 0.679 ）. Conclusions Fluoride iontophoresis was effective in promoting incipient enamel remineralization, although no differences could be observed between fluoride iontophoresis 1.23% acidulated phosphate fluoride gel.

关 键 词：氟离子导入 早期釉质龋 釉质再矿化 pH循环 

分 类 号：R780.1[医药卫生—口腔医学]