激光治疗对婴幼儿皮肤血管瘤患者血浆VEGF及bFGF表达的影响  

Influences of laser treatment on the expressions of the plasma vascular endothelial growth factor and basic fibroblast growth factor in children cutaneous hemangioma

作　　者：徐荣建[1] 王法刚[1] 党伟[1] 曹永倩[1] 林莉[1] 韦浩[1] 赵君[1] 国丽[1] 

机构地区：[1]山东大学附属省立医院烧伤整形科,济南250021

出　　处：《山东大学学报（医学版）》2013年第4期96-99,共4页Journal of Shandong University:Health Sciences

摘　　要：目的探讨激光治疗对婴幼儿皮肤血管瘤患者血浆血管内皮细胞生长因子(VEGF)及碱性成纤维细胞生长因子(bFGF)表达水平的影响。方法选取在我院美容门诊接受激光治疗的腹部表浅血管瘤患者109例,其中增生期患者74例,消退期患者20例,消退完成期患者15例;对照组10例为在我院小儿外科接受治疗的非血管瘤患者。酶联免疫吸附分析法检测各组患者外周血血浆中VEGF及bFGF浓度,并对其中23例增生期血管瘤患者激光治疗前后血浆中VEGF及bFGF浓度的变化进行动态观察。采用SPSS16.0软件包对数据进行统计学处理。结果增生期血管瘤患者血浆VEGF浓度明显高于消退期、消退完成期患者及对照组(P<0.01);增生期患者血浆bFGF浓度明显高于消退期、消退完成期患者及对照组(P<0.01);血管瘤患者激光治疗后血浆中VEGF及bFGF浓度较激光治疗前均显著降低(P<0.01)。结论婴幼儿皮肤血管瘤激光治疗后,血浆中VEGF及bFGF的浓度下降;VEGF及bFGF有望成为评判婴幼儿皮肤血管瘤激光治疗效果的客观检测指标。Objective To investigate the influences of laser treatment on the expressions of the plasma vascular endotheli- al growth factor （VEGF）and basic fibroblast growth factor （bFGF） in children cutaneous hemangioma. Methods 109 infant hemangioma patients with laser treatment from October 2009 to August 2012 were engaged in this study, including 74 proliferative phase patients, 20 involuting phase patients and 15 involuted phase patients. 10 non-hemangioma patients were selected as the control. The blood plasma of all the patients were collected for the further test. The plasma levels of VEGF and bFGF were measured with the enzyme-linked immunosorbent assay（ELISA）. The plasma levels of VEGF and bFGF of 23 proliferative phase patients were dynamically observed before and after the treatment. The data were analyzed with SPSS 16.0 software package. Results The plasma VEGF levels in the proliferating group were significantly higher compared with the involuting,involuted group and the negative control. The plasma bFGF levels of the proliferating group were significantly higher compared with the left three groups. The plasma VEGF and bFGF levels significantly decreased after the laser treatment. Conclusion The plasma VEGF and bFGF concentrationsdecrease after the laser treatment in infant hemangiomas. VEGF and bFGF may be the objective index to judge the effect of the laser treatment on infant hemangiomas.

关 键 词：婴幼儿 血管瘤 激光治疗 血浆 血管内皮细胞生长因子 碱性成纤维细胞生长因子 

分 类 号：R732.2[医药卫生—肿瘤]