缺血缺氧预适应对抗脑缺血缺氧损伤的机制研究进展  

Research Progress in the Mechanisms of Cerebral Ischemia Hypoxia Preconditioning Antagonizing Cerebral Ischemia and Hypoxia Injury

作　　者：袁恒杰[1] 娄建石[2] 

机构地区：[1]天津医科大学总医院药剂科 [2]天津医科大学基础医学院药理教研室

出　　处：《神经药理学报》2011年第4期42-47,共6页Acta Neuropharmacologica

基　　金：国家自然科学基金项目(No.81102447);天津市自然科学基金重点项目(No.09JCZDJC21100)

摘　　要：缺血缺氧预适应现象最初见于心脏,一经发现即引起了学术界的广泛关注,随后研究者分别从不同层面证实了大脑同样具有预适应现象,并进行了大量的研究,成为抗脑缺血缺氧研究的热点。脑缺血缺氧预适应(cerebral ischemia/hypoxia preconditioning,CIP)可以通过多种信号传导途径,减少细胞凋亡,提高机体抗氧化能力,减少氧化损伤,升高低氧诱导因子和热休克蛋白HSP70的生成等,各种机制相互联接,相对独立。The phenomenona of ischemia/hypoxia preconditioning were first discovered in heart. Numerous studies, carried out at different levels,have confirmed that there are also preconditioning phenomenona in brain,and the phenomenona of ischemia/hypoxia preconditioning in brain have become a hot topic in the field of ischemia and hypoxia. Cerebral ischemia/hypoxia preconditioning （CIP） can decrease cell apoptosis,increase the anti-oxidant ability and decrease oxidant injury, increase the generation of hypoxic inducible factor-1 and heat shock protein 70 through multiple signal transduction pathways. There are interactions among the mechanisms about CIP which are relatively independent.

关 键 词：缺血缺氧预适应 细胞凋亡 活性氧 信号传导 低氧诱导因子 热休克蛋白质类 

分 类 号：R743[医药卫生—神经病学与精神病学]