第二次经尿道膀胱肿瘤电切术预防高危非肌层浸润性膀胱癌术后肿瘤复发的临床研究  

Clinical research of repeat transurethral resection of the bladder tumor in preventing the recur- rence of high-risk non-muscle-invasive bladder cancer

作　　者：黄韬[1] 王淼[1] 王勇军[1] 汪良[1] 蒋国松[1] 曾甫清[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院泌尿外科,武汉430022

出　　处：《临床外科杂志》2013年第2期98-100,共3页Journal of Clinical Surgery

基　　金：国家自然科学基金资助项目（No.81001132）

摘　　要：目的探讨高危非肌层浸润性膀胱癌患者行二次经尿道膀胱肿瘤电切（TURBT）术的意义。方法已行第一次TURBT的高危非肌层浸润性膀胱癌患者70例随机分为对照组和二次TURBT：对照组患者在电切术后行膀胱内化疗药物（丝裂霉素C）灌注治疗；二次TURBT组完成对照组治疗，术后3个月第一次复查时行第二次TURBT为实验组。两组患者随访2年，观察肿瘤复发的情况。结果2年内实验组患者膀胱肿瘤的复发率相比对照组患者的复发率显著降低（P〈0．05）。结论第二次TURBT术能有效降低高危非肌层浸润性膀胱癌患者术后肿瘤复发率。Objective To investigate the significance of repeat transurethral resection of the blad- der tumor（re-TURBT） in patients with high-risk non-muscle-invasive bladder cancer（NMBC）. Methods A total of 70 patients with high-risk NMBC who had been treated with the first transurethral resection of the bladder tumor （TURBT） were divided into the control group and the re-operation group. In the control group, patients were treated with bladder Mitomycin C （MMC）bladder irrigation ＇after the first TURBT. In the re-operation group, patients received the same treatment as the control group and then underwent re- TURBT at the first review after three months of the first resection. All the patients were followed-up for 2 years. Tumor recurrence rate was observed. Results During the follow-up, there was a significant reduc- tion in the recurrence rate in the re-operation group compared with the control group（ P 〈0.05 ）. Conclu- sion The recurrence rate of high risk NMBC could be decreased effectively by re-TURBT.

关 键 词：经尿道膀胱肿瘤电切术 膀胱灌注化疗 高危非肌层浸润性膀胱癌 丝裂 霉素C 

分 类 号：R737.14[医药卫生—肿瘤]