降血脂分子机制的研究进展  

Advance of the molecular lipid-lowering mechanisms

作　　者：黄贵东[1] 谭思荣[1] 高冰[1] 郭姣[2] 苏政权[2] 

机构地区：[1]广东药学院药科学院,广州510006 [2]广东药学院中医药研究院,广州510006

出　　处：《中国新药杂志》2013年第8期910-914,共5页Chinese Journal of New Drugs

基　　金：国家自然科学基金(81173107);广东省科技计划项目(2010B090400467);广州市科技计划项目(11A52130094)

摘　　要：随着人们生活水平的日益提高,高脂食物摄入不断增加,引起体内脂质代谢平衡紊乱,导致高血脂患者数量急剧增多。降血脂物质主要通过对胆固醇和甘油三酯的体内合成代谢及相关的酶类活性产生效果。本文对降血脂物质降低血脂的分子机制研究进展进行综述。With the rise of life standards, high-fat food intake is increasing. It causes balance disorders of metabolism, leading to a sharp increase in the number of patients with high cholesterol. Lipid-lowering agents mainly have effects on synthesis of cholesterol and zymes. This paper is a review of researches on mol gents triglyceride in vivo and activity of the metabolism-related en- ecular mechanisms of lowering blood lipids by lipid-lowering agents.

关 键 词：高脂血症 降血脂 胆固醇 甘油三酯 分子机制 

分 类 号：R972.6[医药卫生—药品]