阿立哌唑增效治疗难治性抑郁症的有效性和安全性的系统评价  

Systematic review on the efficacy and safety of aripiprazole combinded with antidepressants in the treatment-resistant depression

作　　者：卢葭[1,2] 陈亮[3] 谢鹏[1,2] 

机构地区：[1]重庆医科大学第一附属医院神经内科,重庆400016 [2]重庆医科大学神经科学中心,重庆400016 [3]重庆市第五人民医院神经内科,重庆400062

出　　处：《中国医院药学杂志》2013年第8期627-632,共6页Chinese Journal of Hospital Pharmacy

基　　金：国家重点基础研究发展计划(973计划;编号:2009CB918300)

摘　　要：目的:评价阿立哌唑联合抗抑郁药治疗难治性抑郁症(TRD)的有效性和安全性。方法:检索Cochrane Library、Med-line、Embase、中国生物医学文献数据库(CBM)、中文科技期刊数据库(VIP)、中国期刊全文数据库(CNKI)、万方数字化期刊全文数据库,查找阿立哌唑治疗难治性抑郁症的随机对照试验(RCT),评价纳入的RCT,采用RevMan 5.1软件进行Meta分析。结果:共纳入14项RCT,包括1 718例TRD患者。Meta分析结果提示,阿立哌唑组的痊愈率和有效率明显优于对照组;阿立哌唑组静坐不能、失眠、疲倦、视物模糊、震颤的发生率高于对照组,食欲减退的发生率低于对照组。结论:阿立哌唑联合抗抑郁药治疗TRD有良好的疗效,但应注意其不良反应的发生。OBJECTIVE To assess the efficacy and safety of aripiprazole combined with antidepressants in the treatmentresistant depression （TRD）. METHODS The Cochrane Library, Medline, Embase, CBM, VIP, CNKI and Wanfang database were searched to identify randomized controlled trials （RCT） comparing aripiprazole with control in patients with TRD. The data were analyzed by using RevMan 5.1 software. RESULTS 14 trials including 1 718 participants were incorporated. The results of Meta-analysis showed that： the effectiveness and the cure rate of the aripiprazole group were significantly higher than those of the control group. The sysnptoms of akathisia, insomnia, languor, blurred vision and the tremor rates of the aripi prazole group were higher than those of the control group. The anorexia rate of the aripiprazole group was lower than that of the control group. CONCLUSION Aripiprazole combined with antidepressants was effective in the treatment of TRD patients. But the side effects of this treatment should be considered.

关 键 词：阿立哌唑 难治性抑郁 有效性 安全性 META分析 系统评价 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R749.153[医药卫生—临床医学]