新疆地区遗传性非息肉病性大肠癌健康教育的开展与应用  

The application of health education to hereditary nonpolyposis colorectal cancer families in the region of Xinjiang

作　　者：宣泱[1] 齐芸[1] 朱二军[1] 周月琪[1] 王刚[1] 张剑权[2,3] 

机构地区：[1]石河子大学医学院,新疆石河子832000 [2]石河子大学第一附属医院普外二科 [3]中南大学湘雅医学院海口医院

出　　处：《现代预防医学》2013年第9期1693-1695,共3页Modern Preventive Medicine

基　　金：国家大学生创新性实验计划(101075933);国家自然科学基金资助项目(81060035);兵团博士资金专项(2010JC17)

摘　　要：目的近年来,在新疆多民族聚居区,由于受居住环境、生活习惯、饮食规律等多因素的影响,HNPCC家系中发病人数有趋于增多之势。为降低HNPCC患者发病率,提高早期诊断率,对已筛查出的新疆地区遗传性非息肉病性大肠癌(HNPCC)家系进行健康教育。方法依照Bethesda指南(2004年)从新疆地区大肠癌患者中筛查出12个HN-PCC家系(8个符合中国人群HNPCC标准,4个同时符合AmsterdamⅡ标准)。对12个家系进行健康教育,并动员HN-PCC家系遗传受累高危人群来院检查,统计随访结果。结果实施健康教育后,12个家系人群对HNPCC知晓率较健康教育前提高,生活习惯改善情况优于健康教育前,腺瘤性息肉检出率增高。以上差异均有统计学意义(P﹤0.05)。结论在新疆地区开展HNPCC家系健康教育,对提高HNPCC家系成员三早预防意识,改变不良生活方式,延缓和减少恶性肿瘤的发生有重要作用。OBJECTIVE Xinjiang has different minorities.The change of living environment,lifestyle and eating habit result in an increase morbidity on HNPCC-related cancer.Applying health education to hereditary nonpolyposis colorectal cancer（HNPCC）families screened out in the region of Xinjiang,to reduce the happening of HNPCC and improve early diagnosis rate.METHODS According to the Bethesda guidelines（2004）,12 HNPCC families were screened（8 families fulfilled both the Amsterdam Ⅱ criteria and the Chinese HNPCC criteria,while the other 4 families fulfilled the Chinese HNPCC criteria only）in Xinjiang.Health education was applied on 12 HNPCC families and HNPCC families members in high risk of genetic involvement to were encouraged to take examinations.Statistically analyzed follow-up results.RESULTS Statistical results after education showed the awareness to HNPCC knowledge was higher than that before education,the improvement of lifestyle was better than that before education,the detection rate of adenomatous polyp increased.These differences were statistically significant（P﹤0.05）.CONCLUSION Health education to HNPCC families has an important effect on the awareness of early prevention,the change of bad lifestyles and then reduction of the incidence of malignant tumors.

关 键 词：大肠癌 遗传性非息肉病 健康教育 家系 随访 

分 类 号：R735.34[医药卫生—肿瘤]