MMP-2、MMP-9及TIMP-2、TIMP-1在非黑色素性皮肤癌中的表达  

Expression of MMP-2, MMP-9, TIMP-2 and TIMP-1 in non-melannoma skin carcinoma

作　　者：张红[1] 邬时国[1] 干亚丹[1] 

机构地区：[1]浙江省余姚市人民医院普外科,浙江余姚315400

出　　处：《中国现代医生》2013年第11期103-105,F0003,共4页China Modern Doctor

基　　金：国家自然科学基金项目(81000705)

摘　　要：目的探讨金属基质蛋白酶MMP-2、MMP-9及其抑制因子TIMP-2、TIMP-1在非黑色素性皮肤癌中的表达。方法取皮肤癌手术切除标本40份,进行免疫组化检测MMP-2、MMP-9及其抑制因子TIMP-2、TIMP-1的表达。结果 MMP-2、MMP-9在非黑色素皮肤癌中的表达的阳性率、染色强度、表达强度均显著高于正常皮肤。TIMP-2、TIMP-1在非黑色素皮肤癌中的表达的阳性率、染色强度、表达强度均显著低于正常皮肤。结论基质金属蛋白酶(MMP)在非黑色素性皮肤癌中呈高表达,基质金属蛋白酶组织抑制因子呈低表达,两者比例失衡与皮肤癌的浸润和转移有关。Objective To discuss expression of MMP-2, MMP-9, TlMP-2 and TIMP-1 in non-melannoma skin car- cinoma. Methods Forty cases of non-melannoma skin carcinoma specimen were selected. MMP-2, MMP-9, TIMP-2 and TIMP-1 were detected. Results Positive rates, staining intensity, expression intensity of MMP-2, MMP-9 in non- melannoma skin carcinoma were higher than normal skin tissue, ositive rates , staining intensity, expression intensity of TIMP-2 and TIMP-1 in non-melannoma skin carcinoma were Sower than normal skin tissue. Conclusion MMPs show high expression in non-melannoma skin carcinoma, and TIMPs show low expression.Imbalance of them connect with non-melannoma skin carcinoma infiltration and metastasis.

关 键 词：皮肤癌 MMP-2 MMP-9 TIMP-2 TIMP-1 

分 类 号：R739.5[医药卫生—肿瘤]