单唾液酸四己糖神经节苷脂对急性脑卒中患者认知及神经功能的影响  

The influence of monosialoteterahexosyl ganglioside on cognitive and neurological function in patients with acute stroke

作　　者：周旭东[1] 张力明[1] 叶昌俊 

机构地区：[1]浙江省平阳县人民医院神经内科,浙江平阳325400

出　　处：《中国现代医生》2013年第13期60-61,64,共3页China Modern Doctor

基　　金：浙江省医学会临床科研基金资助项目(Y2011ZYC-A71)

摘　　要：目的探讨单唾液酸四己糖神经节苷脂对急性脑卒中患者认知及神经功能的影响。方法选择住院治疗的脑卒中患者80例,随机分为观察组和对照组各40例。两组患者均酌情予以降颅内压、营养脑细胞、控制血压血糖等对症支持治疗。观察组在上述处理基础上予以单唾液酸四己糖神经节苷脂注射液60mg加入5%葡萄糖或生理盐水250mL中静滴,每日1次,连用2周;对照组在此基础上予以脑活素注射液20mL加入5%葡萄糖或生理盐水250mL中静滴,每日1次,连用2周。结果治疗2周后,两组患者MMSE评分和WMS评分均有明显上升(P<0.05或P<0.01),且观察组MMSE及WMS评分上升值较对照组更明显(P<0.05)。且观察组神经功能改善的临床总有效率明显高于对照组(χ2=7.81,P<0.01)。两组患者治疗期间未出现严重的不良反应。结论单唾液酸四己糖神经节苷脂治疗急性脑卒中具有较好的临床疗效,安全性良好,提高患者的认知及神经功能,改善预后。Objective To investigate the influence of monosialoteterahexosyl ganglioside on cognitive and neurological function in patients with acute stroke. Methods All of 80 hospitalized patients with stroke were randomly divided into observation group and control group. Patients in both groups were given symptomatic and supportive treatment of re- ducing intracranial pressure, nourishing brain cell, controlling blood pressure, blood sugar and so on. The observation group were given injection of 60 mg monosialoteterahexosyl ganglioside added to 250 mL of 5% glucose or saline infu- sion on the basis, once daily for two weeks; The control group were given brain activator injection 20mL added to 250 mL of 5% glucose or saline infusion,once daily for two weeks. Results After two weeks of treatment,the MMSE score and WMS score of the two groups of patients have increased significantly （P 〈 0.05 or P 〈 0.01 ）, and the rise in the observation group was more obvious than that in the control group （P 〈 0.05）.And the total recovery of neurological function of the observation group had significantly higher efficiency（χ2=7.81 ,P 〈 0.01 ）.There were no serious adverse reactions in the two groups of patients during treatment. Conclusion The usage of monosialoteterahexosyl ganglioside in the treatment of acute stroke have good clinical efficacy and safety, which can significantly improve patients cogni- tive function, promote the recovery of neurological function and patient＇s body and mind, and finally improve the prognosis of the patients.

关 键 词：急性脑卒中 神经节苷脂 认知功能 神经功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]