尼麦角林治疗腕管综合征疗效分析  

Analysis of therapeutic effects of Nicergoline in treatment of carpal tunnel syndrome

作　　者：唐娜[1] 李志军[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院,武汉430030

出　　处：《内科急危重症杂志》2013年第2期82-84,共3页Journal of Critical Care In Internal Medicine

摘　　要：目的:观察尼麦角林治疗轻中度腕管综合征(CTS)的疗效。方法:将68例CTS患者随机分为2组,尼麦角林组给予尼麦角林联合皮质类固醇治疗,地巴唑组给予地巴唑联合皮质类固醇治疗,4、12周后观察临床疗效和神经电生理变化。结果:尼麦角林组治疗后4周症状严重程度评分(SSS)和功能评分(FSS)较治疗前明显改善(均P<0.05);12周时其效果更为明显(P<0.05),与地巴唑组比较,有统计学差异(P<0.05)。神经电生理指标表现为不同程度的改善,其中尤其以环指正中、尺神经感觉潜伏期差值恢复最显著。结论:尼麦角林联合皮质类固醇能有效改善轻中度CTS临床症状和电生理指标,并取得持久的缓解。Objective： To observe the therapeutic effects of Nicergoline in treatment of mild and moderate carpal tunnel syndrome （CTS）. Methods： Sixty-eight cases with CTS were randomly divided into 2 groups, treated with either Nicergoline or dibazol combined with corticosteroid. Therapeutic effects and electrophysiologieal parameters were observed after 4 weeks and 12 weeks, respectively. Results： Symptom severity score （SSS） and functional status score （FSS） in Nicergoline group improved significantly after 4 weeks, in comparison with baseline values （P 〈0.05） , and were more prominent at 12 weeks （P 〈 0.05 ）. Compared with that of dibazol, Nicergoline was more effective at 12 weeks （P 〈0.05）. There were various de- grees of improvement in electrophysiological values after Nicergoline treatment, the sensory latency differences between the median and the ulnar wrist-to-digit were the better parameters in the median nerve recovery after treatment than the median sensory distal latency. Conclusion：Nicergoline combined with corticosteroid could achieve long-term amelioration in treatment of mild or moderate CTS in respect of improving the clinical symptoms and electrophysiological parameters.

关 键 词：尼麦角林 腕管综合征 神经电生理 

分 类 号：R746[医药卫生—神经病学与精神病学]