紫激光辐射人肺组织的光学特性  

Optical Properties of Normal and Cancerous Human Lung Tissues Irradiated by a Violet Kr^+ Laser

作　　者：谢树森[1] 郑蔚[1] 李步洪[1] 林棋榕[1] 黄志伟[2] ChiaTeck-Chee 

机构地区：[1]福建师范大学激光研究所,福州350007 [2]新加坡南洋理工大学理学院

出　　处：《光学学报》2000年第2期229-233,共5页Acta Optica Sinica

基　　金：国家自然科学基金!资助项目 ( 697780 2 9);福建省科委国际合作计划资助项目

摘　　要：应用光纤探测系统和自行研制的光纤探针深度计,成功实现了Kr+紫激光辐射新鲜离体人肺组织体表面漫反射率和内部光能流率分布的精确测定,并利用漫射理论和加倍(AddingDoubling)方法的部分结论,获得了紫光人肺癌组织和正常组织的主要光学特性参数,与蒙特卡罗法拟合实验的光分布曲线得出的结果一致。为临床实际应用提供了重要的原始参数。By using a “Depthometer with an isotropic fiber optic probe” developed by the authors, the diffuse reflectance as well as the fluence rate distributions in the normal and cancerous human lung tissues irradiated by a collimated broad beam of a violet Kr + laser(406.7~415.4 nm) have been accurately measured. In combination with the diffusion theory and the Adding Doubling technique, the optical characteristics of human lung tissues, such as the absorption and the reduced scattering coefficients, the penetration depth and the effective attenuation coefficient, were derived. The experimental data agree well with the fitting results by Monte Carlo simulations. It is believed that this original set of data on the optical parameters will be very useful for the lung cancer photodynamic diagnosis (PDD) and the light dosage designations.

关 键 词：光学特性 人肺组织 紫激光 蒙特卡罗模拟 肺癌 

分 类 号：R734.2[医药卫生—肿瘤]