放疗联合TRAIL治疗在肿瘤治疗中的应用前景  

Prospect of Radiotherapy Combined with TRAIL for Cancer

作　　者：何丽梅[1] 欧阳学农[1] 余宗阳[1] 李捷[1] 

机构地区：[1]福建医科大学福总临床医学院,南京军区福州总医院,福建福州350025

出　　处：《肿瘤学杂志》2013年第4期296-301,共6页Journal of Chinese Oncology

摘　　要：肿瘤坏死因子相关诱导凋亡配体(TRAIL)是肿瘤坏死因子(TNF)家族的新成员,具有广谱、高效、安全的抗肿瘤作用。在临床前的体外实验及移植瘤中,其与放疗联合显示出协同抗肿瘤效应和良好的安全性,具有广阔的临床应用前景。文章就TRAIL的分子生物学特性、放疗与TRAIL联合模式及其优势作一综述。Tumor necrosis factor related apoptosis-inducing ligand （TRAIL） is a new member of TNF super family,with broad, efficient and safe antitumor activity. It has showed synergistic and safe antitumor effect while TRAIL combined with radiotherapy in the preclinical experiment in vitro and in vivo,with a wide prospect in clinic. The molecular biological characteristics of TRAIL, the combination mode of radiotherapy and the superiority were reviewed in this paper.

关 键 词：凋亡 放疗 TRAIL 肿瘤 治疗 

分 类 号：R730.5[医药卫生—肿瘤]