口服普萘洛尔治疗婴幼儿血管瘤的临床观察  

The Clinical Observation on Infantile Hemangioma Treated with Propranolol

作　　者：林晓斌[1] 蔡湘娜[2] 纪影畅[2] 李吉林[3] 郑练[1] 

机构地区：[1]汕头大学医学院第一附属医院小儿外科,广东汕头515041 [2]汕头大学医学院第一附属医院整形外科,广东汕头515041 [3]汕头大学医学院第一附属医院心血管内科,广东汕头515041

出　　处：《汕头大学医学院学报》2013年第1期33-34,37,共3页Journal of Shantou University Medical College

基　　金：广东省医学科学技术研究基金资助项目(B2012252)

摘　　要：目的:探讨小剂量普萘洛尔治疗婴幼儿血管瘤的疗效和安全性。方法:血管瘤患儿随机分为治疗组(30例。口服普萘洛尔0.5～2mg.kg-1.d-1))及对照组(30例。口服维生素C0.5～2mg.kg-1.d-1),疗程均1～9个月。结果:治疗组显效9例,有效19例,无效2例,有效率93.3%;对照组显效1例,有效8例,无效21例,有效率30.0%(P<0.05)。治疗组心动过缓2例,食欲下降2例;结论:普萘洛尔治疗婴幼儿血管瘤疗效显著,不良反应少,安全性较高,可作为婴幼儿血管瘤的一线用药。Objective：To explore the efficacy and safety of propranolol in the treatment of infantile hemangioma.Methods：A total of 60 infants with hemangioma was classified into treatment group（taken orally propranolol 0.5 ～ 2.0 mg·kg-1.d-1）and control group（taken orally Vitamin C 0.5 ～ 2.0 mg·kg-1.d-1）.The course was 1 to 9 months.Results：In the treatment group,there were 9 cases with marked effect,19 cases with effective results,2 cases with no-effect,and the efficiency was 93.3.In the control group,the excellent result was one case,8 cases with effective results,21 cases with no-effect,and the efficiency was 30.0%（P0.05）.The tachycardia and anorexia were found,each 2 cases in the treatment group.Conclusion：Propranolol is effective and safety as first-line treatment for infantile hemangioma.

关 键 词：普萘洛尔 血管瘤 婴幼儿 

分 类 号：R739.8[医药卫生—肿瘤]