细胞因子激活前脂细胞在脂肪移植术中的作用  

THE FUNCTION OF CYTOKINE-ACTIVATED PREADIPOCYTES IN FAT TRANSPLANTATION

作　　者：靳元嵘[1] 杨瑟飞[2] 

机构地区：[1]河北省保定市第一人民医院口腔科,071000 [2]解放军总医院口腔科

出　　处：《中国煤炭工业医学杂志》2013年第4期553-555,共3页Chinese Journal of Coal Industry Medicine

摘　　要：目的探讨碱性基因重组型成纤维细胞生长因子(recombinant basic fibroblast growth factor,bF-GF)与葡聚糖颗粒形成缓释体对脂肪移植体的最终体积和组织学的影响。方法制备bFGF-葡聚糖的缓释颗粒和生理盐水-葡聚糖对照颗粒,加入鼠脂肪珠后,植入鼠背部,用常规组织学方法,光镜检测移植后12、24周的组织学变化,用注射器刻度测量24周体积。结果与对照组比较,脂肪移植体体积在24周时试验组明显高于对照组(P<0.01)。结论 bFGF缓释体可以激活前脂细胞,最大限度保持脂肪移植后的最终体积,可以大幅度地提高脂肪移植术后体积。为今后口腔颌面外科及其他整形外科脂肪移植术的改进提供可能的方法。Objective To investigate the effect of recombinant basic fibroblast growth factor（ bFGF ）deliv- ery system on the volume and histological changes of the transplanted fat tissue. Methods bFGF- dextran and normal saline- dextran delivery system were prepared. The delivery particles were added to fat before transplantation. Measure of the fat volume of 24 weeks and histological changes at 12 and 24 weeks were performed. Results The fat volume of experimental group was larger than that of contrast groups（P^0. 01）. Conclusions bFGF- dextran delivery system can stimulate the adipocytes cell line so that the trans- planted fat grafts can keep a good maintenance of the volume. The new fat transplant technique may be ap- plied in oral maxillofacial surgery or plastic and reconstructive surgery in future.

关 键 词：碱性基因重组型成纤维细胞生长因子 脂肪移植术 葡聚糖颗粒 大鼠 

分 类 号：R782[医药卫生—口腔医学]