血清钙离子水平与肝硬化发病风险相关性研究  

Association between serum calcium levels and the risk of liver cirrhosis

作　　者：尹梁宇[1] 阴建[1] 崔剑峰[1] 刘彬[1] 陈凤[1] 范金虎[1] 陈汶[1] 

机构地区：[1]中国医学科学院肿瘤医院/肿瘤研究所流行病学研究室,北京100021

出　　处：《中华流行病学杂志》2013年第5期457-460,共4页Chinese Journal of Epidemiology

基　　金：美国国立癌症研究所合作项目（N01-RC-47701）

摘　　要：目的探讨成年人血清钙离子水平与肝硬化发病风险间的关系。方法在河南省林县食管癌营养干预试验队列中开展巢式病例对照研究。利用全自动生物化学分析仪和酶联免疫法检测281名肝硬化病例和562名对照个体的基线血清钙浓度以及HBsAg、抗-HBc、抗-HCV，采用调查问卷收集研究对象相关基线特征信息。研究对象血钙水平以三分位分组并使用多因素logistic回归模型计算各组肝硬化发病OR值及其95％CI。结果病例组血清钙离子水平为（1．81±0．84）mmol／L，高于对照组（1．65±0．79）mmol／L，t=-2．640，P=0．008。血清钙的不同取值水平与肝硬化发病率有关（χ2=6．888，P=0．0319）。血钙浓度最高组患肝硬化的风险约为最低组的2倍（OR=2．261，95％CI：1．497。3．416，P=0．002），且血钙水平与肝硬化风险呈正相关（χ2=6．842，P=0．0089）。结论中国人群中高血清钙水平可能作为肝硬化发生一项独立的危险因素，其机制尚需进一步研究。Objective To examine the association between serum calcium levels and the risk of liver cirrhosis. Methods A nested case-control study was performed based on the nutritional intervention trial of esophageal carcinoma in Linxian, Henan province. Serum samples of 281 liver cirrhosis cases and 562 controls were tested for calcium concentrations, surface antigen （HBsAg） and core antibody （anti-HBc） on Hepatitis virus B and antibody on Hepatitis virus C （anti-HCV）, using automatic serum biochemical analysis system and enzyme-linked immunoassay. Data on baseline characteristics were collected via a questionnaire. Serum calcium value was divided into tertiles and logistic regression model was used to calculate odds ratios and 95% confidence intervals. Results Individuals in the case group showed higher calcium levels （1.81±0.84）mmol/L when compared to the controls （ 1.65 ± 0.79）mmol/L, with t=-2.640 and P=0.008. The calcium levels were associated with the risk of liver cirrhosis （χ2=6.888, P=0.0319）. Risks for the individuals in the highest tertile were doubled when compared to the lowest （adjusted OR=2.261,95%CI： 1.497-3.416, P=0.002）. A positive correlation was observed between serum calcium level and the risk of liver cirrhosis （χ2= 6.842, P=0.0089）. Conclusion Results from our study revealed that the elevated serum calcium level might be an independent risk factor for liver cirrhosis. However, further investigations are anticipated to explore its potential mechanisms.

关 键 词：肝硬化 血清钙 巢式病例对照研究 

分 类 号：R575[医药卫生—消化系统]