榄香烯注射液联合铂类化疗药物治疗非小细胞肺癌的Meta分析  

Meta-analysis on elemene injection combined with cisplatin chemotherapeutics in treatment of non-small cell lung cancer

作　　者：徐晓卫[1] 袁拯忠[1] 胡文豪[1] 王晓凯[2] 

机构地区：[1]温州医学院附属第一医院,浙江温州325000 [2]温州医学院,浙江温州325035

出　　处：《中国中药杂志》2013年第9期1430-1437,共8页China Journal of Chinese Materia Medica

基　　金：国家中医药管理局十二五重点学科项目

摘　　要：利用计算机检索Cochrane Library,Web of Science,PubMed,FMJS,中国生物医学文献数据库,维普知识资源系统,中国期刊全文数据库,万方数据知识服务平台,检索时间从各数据库至截止2012年7月5日,同时辅助其他检索,纳入榄香烯联合铂类化疗药物治疗NSCLC的随机对照试验(randomized controlled trials,RCTs),由2名研究员分别独立提取数据和进行文献质量评价,并用RevMan 5.2软件进行Meta分析,系统评价榄香烯注射液联合铂类药物治疗非小细胞肺癌的疗效和安全性,共纳入11篇RCTs,共计病例数为844例,Meta分析结果显示,与单纯含铂类化疗药物相比,榄香烯注射液联合铂类化疗药物可以提高临床获益率(OR=2.03,95%CI:1.43～2.88,P<0.000 1)和生活质量(OR=3.23,95%CI:2.20～4.74,P<0.000 01);减少白细胞下降(OR=0.50,95%CI:0.33～0.76,P<0.001)、血小板下降(OR=0.38,95%CI:0.16～0.85,P<0.02)、提高CD4(MD=3.32,95%CI:2.94～3.70,P<0.000 01),和CD4/CD8(MD=0.36,95%CI:0.28～0.44,P<0.000 01),降低恶心呕吐等胃肠道反应(OR=0.37,95%CI:0.19～0.71,P=0.003)。该文分析提示榄香烯能提高非小细胞肺癌化疗效果,改善生活质量,并降低铂类化疗药物的毒副作用,值得临床推广使用。To research databases of Cochrane library, Web of Science, PubMed, FMJS, CBM, VIP, CNKI and Wanfang Data Konwledge Service Platform by computers as at July 5, 2012, which was supplemented with other search results. The findings were in- cluded into randomized controlled trials （RCTs） of elemene injection combined with cisplatin chemotherapeutics in treating small cell lung cancer （NSCLC）. Data was separately collected by two researchers for literature quality evaluation, and a Meta analysis was made with RevMan 5. 2 software, in order to assess the efficacy and safety of elemene injection combined with cisplatin chemotherapeutics in treating NSCLC. Totally 11 RCTs or 844 cases were included. Meta analysis results suggested that compared with cisplatin chemothera- py alone, the combination of elemene injection and cisplatin chemotherapeutics showed a higher clinical benefit rate （ OR = 2. 03, 95 % CI ： 1.43-2. 88, P 〈 0. 000 1 ） and a better quality of life （ OR = 3.23, 95% CI：2. 20-4. 74, P 〈 0. 000 01 ）. Besides, the combination could also reduce leucopenia （ OR = 0. 50, 95% CI：0. 33-0. 76, P 〈 0. 001 ）, and thrombocytopenia （ OR = 0. 38, 95% CI：0. 16-0. 85, P 〈 0. 02） , increase CD4 （ MD = 3.32, 95% CI：2. 94-3.70, P 〈 0. 000 01 ）, and CD4/CD8 （ MD = 0. 36, 95% CI：0. 28-0.44, P 〈 0. 000 01 ）, and relieve gastrointestinal reactions such as nausea and vomiting （ OR =0. 37, 95% CI ： 0. 19-0. 71, P = 0. 003 ）. The analysis indicates that elemene can enhance the chemotherapeutic effect on NSCLC, improve the quality of life, and reduce adverse effect of platinum-contained chemotherapeutics, thereby being worth promoting in clinic.

关 键 词：榄香烯注射液 化疗 非小细胞肺癌 META分析 

分 类 号：R734.2[医药卫生—肿瘤]