那他霉素微胶囊层层组装体系优化及释放行为  

Optimization for Layer-by-layer Assembly System of Natamycin Microcapsule and Release Behavior

作　　者：卢向阳[1] 刘伟成[1] 卢彩鸽[1] 巨修练[2] 杨万吉[3] 

机构地区：[1]北京市农林科学院植物保护环境保护研究所,北京100097 [2]武汉工程大学化工与制药学院,武汉430074 [3]长江大学农学院,湖北荆州434023

出　　处：《农药》2013年第5期340-343,共4页Agrochemicals

基　　金：北京市自然科学基金资助项目(2122019)

摘　　要：[目的]利用层层组装技术调控那他霉素微胶囊的释放速率。[方法]通过正交试验及组装体电势测定,优化以壁材为海藻酸钠和壳聚糖的组装体系条件。[结果]组装体系的pH值对组装体电势影响最大,NaCl质量浓度、壁材质量浓度、Tween-80质量浓度和温度也有影响;随组装层数增加,组装体的释放速率显著下降。以在水中释放72 h为例,NA原粉、4层和8层组装体的累积释放率分别为5.96%、4.10%和1.95%(质量分数)。[结论]通过组装体系优化及层数的调控,可以获得不同释放速率的微胶囊。[Aims] The release rate of natamycin microcapsules were adjusted with layer-by-layer assembly. [Methods] The conditions of assembly system with wall material of sodium alginate and chitosan were optimized by orthogonal test and electric potential determination. [Results] The pH value of assembly system had a largest impact on the electric potential of assembly, and the concentration of NaCl, wall material, Tween-80 and temperature also had impact. The more the assembly layers, the slower was the release rate of assembled body. To release for 72 h in water, e.g., the cumulative release rate of natamycin original powder, 4-layer and 8-layer assembled body were 5.96, 4.10 and 1.95%（w/w）, respectively. [Conclusions] Different release rates of the microcapsule can be obtained through assembly system optimization and the layer number of regulation.

关 键 词：层层组装 那他霉素 微胶囊 控制释放 

分 类 号：TQ455.4[化学工程—农药化工]