单核细胞趋化蛋白-1和脑梗死患者颈动脉粥样硬化斑块稳定性的关系  

Relationship between the stability of carotid artherosclerosis plaque and the levels of plasma chemoattractant protein-1 in patients with cerebral infraction

作　　者：李运刚[1] 贾汇刚[1] 夏英凯[1] 

机构地区：[1]山东省莱芜钢铁集团有限公司医院神经内科,山东莱芜271126

出　　处：《中风与神经疾病杂志》2013年第4期333-335,共3页Journal of Apoplexy and Nervous Diseases

摘　　要：目的探讨血浆单核细胞趋化蛋白-1(MCP-1)水平与脑梗死患者颈动脉粥样硬化斑块稳定性的关系。方法根据颈动脉彩色多普勒超声仪检查结果,将116例脑梗死患者分为无斑块组(29例)、稳定斑块组(47例)和不稳定斑块组(40例)。采用ELISA法检测脑梗死患者以及30名正常对照组血浆MCP-1水平。分析血浆MCP-1水平与脑梗死患者颈动脉粥样硬化斑块稳定性的关系。结果 (1)不稳定斑块组血浆MCP-1水平明显高于稳定斑块组(P<0.05);(2)脑梗死患者颈动脉斑块稳定性与血浆MCP-1水平呈负相关(r=-0.683,P<0.05)。结论血浆MCP-1水平的增高和颈动脉粥样硬化斑块的不稳定性密切相关。Objective To investigate the relationship between plasma level of chemoattractant protein-1 （ MCP-1 ） and the stability of carotid artherosclerosis plaque in patients with cerebral infraction. Methods According to the results of carotid artery color dopplar ultrasound test, 116 patients with cerebral infarction were divided into no plaques group （29 cases） , stable plaque group （47 cases） and unstable plaques group （40 cases）. The plasma level of MCP-1 was detected by means of enzyme-linked immuno sorbent assay （ELISA） in patients with cerebral infarction and 30 normal controls. The relationship between the stability of carotid artherosclerosis plaque and the levels of plasma level of MCP-1 in patients with cerebral infarction were analyzed. Results （ 1 ） Compared with stable plaque group, the levels of plasma MCP-1 in unstable plaques group was significantly higher （ P 〈 0.05 ）. （2） In patients with cerebral infarction, the stability of carotid plaque was negatively correlated with the levels of plasma MCP-1 （ r = - 0. 683,P 〈 0.05）. Conclusion High plasma MCP-1 level is closely related with carotid artherosclerosis plaque unstability in patients with cerebral infarction.

关 键 词：单核细胞趋化蛋白-1 颈动脉粥样硬化斑块 脑梗死 

分 类 号：R743.1[医药卫生—神经病学与精神病学] R743.3[医药卫生—临床医学]