药物成瘾的表观遗传机制  

Epigenetic mechanisms of drug addiction

作　　者：杨广慧[1] 鲁显福[1] 顾尔伟[1] 

机构地区：[1]安徽医科大学第一附属医院麻醉科,合肥230022

出　　处：《国际麻醉学与复苏杂志》2013年第5期452-455,共4页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基金项目（30972834,81100813）

摘　　要：背景奖赏脑区基因表达异常是药物成瘾的关键基因机制，但决定药物成瘾的表观遗传学机制并不清楚。目的研究慢性外源性药物暴露转变为药物成瘾的表观遗传发病机理。内容综述有关DNA甲基化与组蛋白表观遗传调节药物依赖或成瘾的证据。趋向这些表观遗传变异介导药物滥用与依赖的新颖见解，将为改善药物成瘾的治疗提供新途径。Background Gene expression differences in brain-reward regions are the key genetic mechanisms of drug addiction, yet its epigenetic mechanisms have remained unclear. Objective To explore the epigenetic mechanisms by which chronic exogenous drugs exposure is translated into drug addiction. Content Evidence pertaining to DNA methylation and histone epigenetic regulation and microRNA in drug dependence or addiction is reviewed. Trend These novel insights of epigenetic variations mediating drug abuse and dependence might pave new pathes for improving treatments of drug addiction.

关 键 词：药物成瘾 表观遗传学 DNA甲基化 组蛋白表观遗传调节 小分子RNA 

分 类 号：R74[医药卫生—神经病学与精神病学]