首发抑郁症与复发抑郁症患者血清甲状腺激素水平变化的对比研究  

Comparative study of serum thyroid hormone changes in patients with incipent depression and re- currence depression

作　　者：蒋珊[1] 陈岩[2] 阎琳[1] 卢妍妍[1] 李幼辉[1] 

机构地区：[1]郑州大学第一附属医院,450052 [2]河南省医学会

出　　处：《中国实用医刊》2013年第10期6-7,共2页Chinese Journal of Practical Medicine

摘　　要：目的探讨首发、复发抑郁症患者血清甲状腺激素的水平变化。方法对63例首发、55例复发抑郁症患者及60例健康对照者采用电化学发光免疫分析法测定血清游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）、促甲状腺激素（TSH）的含量。结果①首发与复发组血清FT3、FT4较对照组高（P〈0．01），首发与复发组血清TSH较对照组低（P〈0．01）；②复发组患者FT4高于首发组患者（P〈0．05）。结论首发与复发抑郁症患者血清FT3、FT4较对照组高，TSH较对照组低；复发患者中血清FT4较首发患者高，存在更为明显的甲状腺系统代谢异常。Objective To investigate the serum thyroid hormone changes in patients with incipi- ent depression and recurrence depression. Methods For 63 cases of incipient depression, 55 cases of recurrence depression and 60 healthy controls, using the immunochemieal luminescence, the levels of FT3, FT4 and TSH were tested. Results ①The levels of FT3 and FT4 were higher in incipient depres- sion group and recurrence depression group than those in healthy controls（ P 〈0. 01 ）. The level of TSH was lower in incipient depression group and recurrence depression group than that in healthy controls （ P 〈 O. O1 ）. ②The level of FT4 in recurrent depression group was higher than that in incipient depres- sion group. Conclusions There was thyroid hormone metabolism disorder in incipient depression group and recurrence depression group. FT4 in recurrent group was higher than that in incipient group. And thyroid system metabolic abnormalities is more obvious in recurrent group.

关 键 词：首发抑郁症 复发抑郁症 甲状腺激素 游离三碘甲状腺原氨酸 游离甲状腺素 促甲状腺激素 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R817.4[医药卫生—临床医学]