5×FAD阿尔茨海默病小鼠模型的研究现状及展望  

Development of 5×FAD mouse model of Alzheimer's disease

作　　者：刘建清[1] 马渊[2,3] 

机构地区：[1]江苏正大天晴药业股份有限公司,南京210042 [2]中国中医科学院望京医院,北京100102 [3]达尔豪斯大学心理学及神经科学系

出　　处：《中国新药杂志》2013年第9期1047-1051,共5页Chinese Journal of New Drugs

摘　　要：阿尔茨海默病(Alzheimer's disease,AD)是多种因素共同作用的多病因疾病。因AD的发病机制复杂,现有的动物模型不能满足对其病因及治疗药物研究的需要。携带5个家族性基因突变的APP/PS1转基因AD模型小鼠(transgenic mice with five familial Alzheimer's disease,5×FAD)为新型AD模型小鼠,该转基因小鼠具有与AD相似的功能学及病理变化特征,与其他AD模型动物相比其神经病理学变化更为明显。5×FAD小鼠是可以用于研究AD发病机制、治疗靶点及治疗药物的动物模型。Alzheimer＇s disease （AD） is induced by multiple factors. For the complexity of AD onset, the existing AD animal models are not satisfying enough in research of AD and related therapy. Transgenic APP/PS1 mouse with five familial Alzheimer＇s disease （5 FAD） is new animal model of AD. The 5 FAD mouse shows similar functional and pathological changes with AD process, and has more significant neuropathological characters than other AD animal models. Thus, 5 FAD mouse is suitable animal model for research of onset, molecular targets and therapeutic drugs of AD.

关 键 词：阿尔茨海默病 转基因鼠 动物模型 

分 类 号：R742[医药卫生—神经病学与精神病学]