日尿排泄^(131)I值估算甲状腺癌患者体内残留活度  

Estimation the daily urinary excretion ^(131)I radioactivity of thyroid cancer in patients with residual activity

作　　者：汤敏敏[1] 刘建中[1] 武志芳[2] 陆克义[2] 李思进[2] 

机构地区：[1]山西医科大学研究生学院,太原030001 [2]山西医科大学第一医院核医学科

出　　处：《中国医疗前沿》2013年第6期8-9,共2页China Healthcare Innovation

摘　　要：目的通过测定分化型甲状腺癌患者131I治疗后日尿排泄131I的活度值来估算患者体内残留的131I活度,并结合国家标准预测患者的出院时间。方法测量35例分化型甲状腺癌患者服131I后不同时间各次尿液的放射性活度,计算每位患者不同时间尿液排泄的总活度,进而估算患者体内残留的总活度。结果 "清甲"及"清灶"治疗患者于服131I后第1d尿液内排泄的放射性活度分别为2401.5 MBq、4144.5MBq(占服131I总活度的64.9%、71%),而且"清甲"及"清灶"治疗后患者第1d体内残留131I活度分别为926.9MBq、1081.1MBq(占总131I活度的25.1%、17.2%),其后患者尿液内排泄的131I活度及患者体内残留131I活度下降幅度缓慢。20例"清甲"及15例"清灶"治疗的患者,达到国家标准的出院时间分别为3.1±2.2d、1.9±1.1d。结论甲状腺癌患者服用大剂量131I后短期内对周围环境和人有影响,所以患者必须入院并在规范的辐射防护病房隔离平均2-3d(48-72h)以上方可出院。Objective Through the determination of 131I posttreatment differentiated thyroid cancer patients＇ urine discharge 131I value in one day to estimate the residual 131I radioactivity in vivo, and combined with the national standard predict to forecast the patients＇ discharge time. Methods Measuring each of 35 differentiated thyroid cancer patient＇s urine radioactivity after take 131I, and calculating the total radioactivity in different time of each patient, and then estimating the total residual 131I radioactivity in patients. Results The 131I ablation therapy on remnant thyroid and f31I treatment on metastatic lesions in patients after the first day taking 131I, the urine discharge of radioactivity respectively was 2401.5MBq, 4144.5MBq（respectively accounts for 64.9% and 71% of the total taking 131I radioactivity）, and the 131I ablation therapy on remnant thyroid and 131I treatment on metastatic lesions patients＇ residual 131Iradioactivity in vivo respectively was 926.gMBq, 1081.1MBq（respectively accounts for 25.1% and 17.2% of total 131I radioactivity）, followed by patients in the urine discharge of 131I radioactivity and the residual 131I radioactivity in vivo declines slowly. 20 cases of 131I ablation therapy on remnant thyroid and 15 cases of 131I treatment on metastatic lesions of patients, reach the national standard discharge time respectively was 3.1±2.2days and 1.9± 1 .ldays. Conclusion The thyroid cancer patients who taking large doses of 131I will impact the surroundings and other people in a short term, so the patients must be hospitalized and isolated in the standard protective ward for average 2-3days（48-72h） before discharge.

关 键 词：甲状腺癌 放射性131I 尿液131I测量 体内残留 

分 类 号：R736.1[医药卫生—肿瘤]