奥沙利铂联合常规化疗治疗晚期结肠癌的临床观察  

Clinical Observation of Oxaliplatin Combined with Chemotherapy in Treatment of Cancer of Colon in Advanced Stage

作　　者：陈明岩[1] 杨柳[1] 张军[1] 杨帆[1] 张丹[2] 

机构地区：[1]一汽总医院(吉林大学第四医院)普外科,吉林长春130011 [2]吉林大学中日联谊医院普外科,吉林长春130011

出　　处：《现代生物医学进展》2013年第6期1104-1107,共4页Progress in Modern Biomedicine

摘　　要：目的:研究奥沙利铂(L-OHP)联合化疗治疗晚期结肠癌的疗效。方法:选取60例晚期结肠癌患者,随机分为治疗组和对照组,每组各30例,对照组给予常规化疗治疗,治疗组给予L-OHP联合化疗治疗,观察比较两组的疗效和不良反应。结果:治疗组治疗总有效率(53.3%)显著高于对照组(36.7%)(P<0.05);治疗组中初治患者治疗有效率(63.2%)显著高于复治患者(36.3%)(P<0.05),也显著高于对照组中的初诊患者治疗有效率(38.9%)(P<0.05)。对照组中初治患者治疗有效率(38.9%)和复治患者(30.0%)相当(P>0.05),复治患者的治疗有效率与对照组复治患者相当(P>0.05)。治疗组白细胞减少和神经毒性的发生率要高于对照组(P<0.05),而治疗组出现口腔炎的比例低于对照组(P<0.05),恶心呕吐、腹泻、血小板减少、手足综合征和肾毒性的发生率均相当(P>0.05)。结论:L-OHP联合化疗治疗晚期结肠癌初治患者具有较好的近期疗效和安全性,但其远期疗效和预后尚需进一步研究观察。Objective： To study the therapeutic effect of oxaliplatin combined with chemotherapy in treatment of cancer of colon in advanced stage. Methods： 60 patients with cancer of colon in advanced stage were chosen and divided into treatment group and control group, and 30 cases were in each group. Patients in the treatment group were treated by routine chemotherapy, and those in control group were treated by oxaliplatin combined with chemotherapy. The therapeutic effects and adverse reactions were observed and compared. Results： The total effective rate in treatment group （53.5 %） was significantly higher than that in control group （36.7 %）. The effective rate of pa- tients with initial treatment （63.2 %） in the treatment group was much higher than that of patients with retreatment （36.3 %） （P〈0.05）, and it was also much higher than that in control group （38.9 %） （P〈0.05）. In the control group, the effective rates were nearly same in both undertaking initial （38.9 %） and retreatment cases （30.0 %） （P〉0.05）, and were also nearly same to patients with retreatment in the treat-ment group （P〉0.05）. In the treatment group, the incidence rates of leucopenia and neurovirulence were higher than those in the control group （P〈0.05）, while the incidence rate ofstomatitis was lower than that in the control group （P〈0.05）. The incidence rates of nausea and vomiting, diarrhea, thrombocytopenia, hand-foot syndrome and venenosus were nearly same in both groups （P〉0.05）. Conclusion： Oxaliplatin combined with chemotherapy in treatment of patients with initial treatment is effective in the near future and safe, while the prostecdtive efficacy and prognosis need to be further observated and studied.

关 键 词：奥沙利铂 化疗 结肠癌 

分 类 号：R735.35[医药卫生—肿瘤]