子宫内膜癌中E2F-1和p-p38的表达及相关性分析  

The Expression and Significance of E2F-1 and P-P38 in Endometrial Carcinoma

作　　者：时志民[1] 苗树梁[1] 王蕾[1] 周海霞[2] 司军英[3] 吴彩花[4] 

机构地区：[1]河北工程大学医学院,河北邯郸056001 [2]邯郸市中西医结合医院,河北邯郸056002 [3]邯郸市中心医院,河北邯郸056001 [4]邯郸市传染病医院,河北邯郸056002

出　　处：《现代生物医学进展》2013年第7期1316-1318,1377,共4页Progress in Modern Biomedicine

摘　　要：目的:检测子宫内膜癌组织中E2F-1和p-p38表达情况并探讨其意义。方法:采用免疫组织化学S-P法检测60例子宫内膜癌、32例正常子宫内膜组织中两者的表达。结果:子宫内膜癌组织中E2F-1和p-p38表达定位于细胞核,其阳性表达率分别为58.33%(35/60)和55.00%(33/60)明显高于正常子宫内膜组织,为0、0(P<0.05)。两者的表达与肌层浸润程度、淋巴结转移、临床分期及病理分期有关(P<0.05);在子宫内膜癌组织中E2F-1和p-p38两者之间比较表达呈正相关(P<0.05)。结论:E2F-1和p-p38在子宫内膜癌呈高表达,且与子宫内膜癌的发生、发展和转移密切相关。Objective： To determine the expression of E2F-1 and p-p38 in the endometrial carcinoma and the significance of their expressions. Methods： To detect the expressions of E2F-1 and p-p38 in 60 cases of endometrial cancer and 32 cases of normal endometrial tissue by immunohistochemistry S-P. Results： The expressions of E2F-1 and p-p38 were located with the cytoplasm and the endometrial. The positive expression rates were 58.33% （35/60） and 55.00% （33/60）, respectively, both of which were significantly higher than those with the values of 0 and 0 in normal endometrial tissue （P〈0.05）. All of their expressions were related with myometrial invasion, lymph nodemetastasis, clinical stage and pathological staging（P〈0.05）. In endometrial carcinoma, the expressions of E2F-1 and p-p38 were positively correlated with each other （P〈0.05）. Conclusion： E2F-1 and p-p38 were highly expressed in the endometrial carcinoma,and their expressions were related with the development and metastasis of endometrial carcinoma.

关 键 词：子宫内膜肿瘤 E2F-1 P-P38 免疫组化 

分 类 号：R737.33[医药卫生—肿瘤]