紫杉醇联合米托蒽醌治疗难治性晚期乳腺癌的临床研究  

Clincal study of treating refractory advanced breast cancer with taxol and mitoxantrone

作　　者：郭兴来 钱和生[1] 胡勇 

机构地区：[1]安徽省阜阳肿瘤医院肿瘤内科,236018

出　　处：《淮海医药》2000年第2期98-99,共2页Journal of Huaihai Medicine

摘　　要：目的评价紫杉醇联合米托蒽醌治疗难治性晚期乳腺癌疗效。方法 １２例晚期乳腺癌患者术后复发转移，接受常规方案治疗失败后改用 ＴＭｘ方案化疗：第 １ｄ紫杉醇 １３５ ｍｇ／ｍ２，静脉滴注 ４ ｈ；第 ２ ｄ米托葱醒 ８ｍｇ／ｍ２，静脉滴注３０ ｍｉｎ。每４周重复疗程。结果完全缓解（ＣＲ）２例（１６．７％），部分缓解（ＰＲ）７例（５８．３％）。毒副反应主要有白细胞下降。结论 ＴＭｘ方案是治疗难治性晚期乳腺癌疗效较高的方案，值得进一步研究。Objective To evaluate the therapeutical effect of the combination of taxol and mitoxantrone (TMx) in patients with refractory advanced breast cancer. Methods Twelve patients with relapsed and metastasized breast cancer postoperatively, who underwent failed teratment with conventional regimen,were treated with TMx regimen: Taxol 135 mg/m2, IV drop,day l;Mitoxantrone 8 mg/m2,IV drop, 30min,day2. This treatment repeated every 4 weeks. Results Two patients (16. 7% ) achieved complete remission (CR), 7 patients (58. 3% ) achieved partial remission(PR). Toxicity was mainly leukopenia. Conclusion This result suggests that TMx is an effective regimen in patients with refractory advanced breast cancer and worthly be further studied.

关 键 词：乳腺癌 紫棚醇 米托蒽醌 治疗 

分 类 号：R737.905[医药卫生—肿瘤]