釉基质蛋白各组成成分及其作用  

Components and their individual effects of emdogain

作　　者：邹慧儒[1] 秦宗长[1] 张兰成[1] 

机构地区：[1]南开大学附属口腔医院牙体牙髓病科,天津300041

出　　处：《国际口腔医学杂志》2013年第3期355-358,共4页International Journal of Stomatology

基　　金：天津市卫生局科技基金资助项目(2012KY19)

摘　　要：釉基质蛋白(EMD)为发育期牙釉质中的一系列釉基质物质及其衍生物,具有促进牙周组织再生和生物矿化以及骨诱导等生物学活性。EMD富含牙釉蛋白、釉蛋白和成釉蛋白等多种蛋白质成分,在诱导成骨和促进血管形成等方面都有一定的作用。随着检测技术水平的不断提高,类生长因子活性在EMD中也被检测到,即以EMD代替生长因子应用于组织工程研究是可行的。本文就牙釉蛋白、釉蛋白和成釉蛋白以及蛋白酶和类生长因子物质等EMD的组成和作用等研究进展作一综述,以期为EMD的广泛应用提供一定的参考。Emdogain （EMD） is a product derived from developing enamel which contains various enamel matrix proteins and derivatives. It is believed to act as a tissue-healing modulator which helps stimulate periodontal regeneration, biomineralization and bone induction. Previous studies suggested that EMD contains various proteins, such as amelogenin, enamelin, ameloblastin, which might be involved in bone induction, angiogenic formation etc. Recently, growth-factor like activity has been observed in EMI） which suggested that EMD might be used as another candidate out of growth factors in tissue engineering research. This review summarized the research progress on components and their individual effects of EMD to give an overview for further development of EMD applications.

关 键 词：釉基质蛋白 釉基质衍生物 蛋白质 

分 类 号：R78[医药卫生—口腔医学]