老年非酒精性脂肪性肝病与冠心病的相关性研究  

Correlation between Nonalcoholic Fatty Liver Disease and Coronary Heart Disease

作　　者：林芬[1] 毛旭升[1] 陈崧[1] 

机构地区：[1]福建省级机关医院内科,福州350003

出　　处：《福建医药杂志》2013年第2期6-8,共3页Fujian Medical Journal

基　　金：福建省卫生厅青年科研课题(2009-2-33)

摘　　要：目的研究老年非酒精性脂肪性肝病(NAFLD)与冠心病(CHD)的相关性,阐明其作为CHD预测因素的价值,为CHD的预防和治疗提供资料和依据。方法 82例接受冠状动脉造影检查的患者,并有糖、脂代谢指标及腹部超声检查结果。男35例,女47例;年龄61～83岁,平均年龄68.7岁。分析两组间冠脉造影的结果差异,并采用Logistic回归法分析增加CHD患病风险的独立危险因素。结果 NAFLD组的体质量指数、空腹血糖、TG均显著高于非NAFLD组(P<0.05),NAFLD患者中CHD发生率明显高于非NAFLD患者,合并NAFLD的CHD患者以多支病变为主(P<0.05),且冠状动脉病变程度较重。通过Logistic回归分析发现,使CHD患病风险增加的独立危险因素有NAFLD和年龄。结论 NAFLD与CHD的发病及其病变程度呈正相关,可成为CHD的独立危险因素,可用其初步评估心血管事件发生的危险程度。Objective To explore the possible relationship between nonalcoholic fatty liver disease （NAFLD） and coro- nary heart disease （CHD）. Methods Totally＇82 subjects underwent coronary angiography, including 35 men and 47 women with complete data on metabolic syndrome andabdominal ultrasonography~ the mean age was 68.7 years. The single parameter that best predicted CHD was analysed by multiple stepwise regression. Results The body mass index （BMI）, fasting blood glucose, triglycerides were higher in NAFLD patients than in patients without NAFLD （P（0.05）. The prevalence of CHD in the NAFLD group was significantly higher than that in the non-NAFLD groups. Most patients in the CHD-NAFLD group had multivessel lesions in the coronary artery （P^0.05）. Logistic regression analysis indicated that NAFLD and age independently increased the risk of CHD. Conclusion NAFLD is an independent predicator for CHD and is related to the severity of CHD.

关 键 词：非酒精性脂肪性肝病 冠心病 危险因素 

分 类 号：R575.5[医药卫生—消化系统] R541.4[医药卫生—内科学]