胃肠道间质瘤39例临床病理分析  

A clinicopathological study of gastrointestinal stromal tumor in 39 cases

作　　者：余茂武[1] 丁顺[1] 

机构地区：[1]福建省宁德市医院病理科,宁德352100

出　　处：《福建医药杂志》2013年第2期86-88,共3页Fujian Medical Journal

摘　　要：目的探讨胃肠道间质瘤(gastrointestinal stromal tumor,GIST)的临床、病理及免疫组化特征。方法收集2005年3月至2012年10月我院收治的39例GIST患者的临床及病理资料。结果 GIST临床表现无特异性,最常发生于胃,占51.3%(20/39),其次是小肠,占33.3%(13/39);肿瘤体积最大者15cm×13cm×8cm,最小者0.5cm×0.5cm×0.5cm;极低危6例,低危10例,中危7例,高危16例;CD117阳性率94.9%(37/39),CD34阳性率71.8%(28/39)。结论 GIST发生部位多,形态学复杂,诊断主要依靠术后病理切片及免疫组化检测,GIST肿瘤的大小、核分裂像、侵犯转移等均是判定肿瘤恶性程度的重要指标,早期诊断、采取合理的治疗有利于改善预后。Objective To investigate the clinical diagnosis and treatment, clinicopathology Immunohistochemistry of gas trointestinal stromal tumors （GIST）. Methods A retrospective analysis of clinical data was conducted in 39 patients with GIST who were admitted in our hospital from March 2005 to October 2012. Results All patients had no clinical specificity. This occured most often in the stomach group, and the rate was 51.3% （20/39）, followed by the small intestine 33.3% （13/39）. Tumor volume sizes, the largest 15 cmX13 cmX8 era, smallest 0.5 cm×0.5 cm×0.5 cm. Very low risk in 6 cases, low risk in 10 cases, intermediate risk in 7 cases, and high risk in 16 cases. The positive rate of CDl17 was 94.9% （37/39） and the positive rate of CD34 was 71.8% （28/39）. Conclusion GIST occurrence site and morphology complex, diagnosis mainly de- pends on the postoperative pathology and immunohistochemistry, tumor size, mitotic figures, invasion and metastasis are im- portant index to judg degree of malignancy, early diagnosis and proper treatment can improve the prognosis.

关 键 词：胃肠道间质瘤 临床病理 免疫组化 

分 类 号：R735.2[医药卫生—肿瘤]