Myc族癌基因与食管癌相关性的研究  

A relative study on the expression of myc oncogene and esophageal carcinoma

作　　者：杨立峰[1] 王跃江[1] 佟倜[2] 纪振东[2] 

机构地区：[1]吉林铁路中心医院胸外科,吉林132001 [2]白求恩医科大学第一临床学院

出　　处：《中国肿瘤临床与康复》2000年第5期16-17,共2页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的　通过检测食管癌组织中myc族癌基因的扩增情况探讨myc族癌基因与食管癌发生、发展及预后的关系。方法　聚合酶链反应 (PCR)测定。结果　myc族癌基因的阳性扩增率 5 5 .0 % (11/2 0 )。其过表达与肿瘤分化程度、浸润范围、淋巴结转移、临床病理分期方面在统计学上有差异 (P <0 .0 5 ) ,而与病人年龄、肿瘤部位在统计学上无差异性 (P >0 .0 5 )。结论　myc族癌基因的过表达与食管癌的生物学行为有关。有可能为食管癌病人的防治及预后判定提供新的方法。Objective To study the relationship between myc oncogene and the biologic behavior and prognosis of esophageal carcinoma.Methods Myc gene expression was assayed using polymerase chain reaction in 20 case of esophageal carcinoma patients.Results Ampilfication of myc gene was found in 11(55%) patients.The presence of myc was not correlated with the age of the patients and the location of the tumor,but correated with tumor lymphnode metastasis and invasion and patient′s prognosis.Conclusions Myc gene closely relates with the biologic behavior and prognosis of esophageal carcinoma,whose amplification may be a marker of malignancy in the development of esophageal carcinoma. [

关 键 词：食管癌 myc族癌基因 基因扩增 

分 类 号：R735.1[医药卫生—肿瘤]