椎旁神经阻滞联合药物治疗老年人肺癌开胸术后肋间神经痛临床疗效观察  

Clinical Efficacy Study on Elderly Lung Cancer Patients with Intercostal Neuralgia after Thoracotomy by Paravertebral Nerve Block Combined Drug Therapy

作　　者：曹雷[1] 李成辉[1] 韩彬彬[1] 刘沙沙[1] 李帆[2] 

机构地区：[1]中日友好医院麻醉科,北京100029 [2]首都儿科研究所附属儿童医院,麻醉科北京100029

出　　处：《现代生物医学进展》2013年第9期1718-1721,共4页Progress in Modern Biomedicine

摘　　要：目的:探讨椎旁神经阻滞联合药物治疗老年人肺癌开胸术后肋间神经痛临床疗效和安全性。方法:选择2010年8月～2012年8月在我院住院治疗的68例肺癌患者为研究对象,运用随机数字表法将符合本研究纳入标准和排除标准的患者分为A组和B组,A组患者给予椎旁神经阻滞,B组患者则给予椎旁神经阻滞的同时加用尼美舒利片进行治疗,比较两组患者临床疗效和安全性。结果:与治疗前比较,两组患者治疗后1、2、3周视觉模拟评分(VAS)和睡眠质量评分(QS)均明显下降,治疗第3周,B组患者视觉模拟评分(VAS)和睡眠质量评分(QS)明显低于A组患者,差异有统计学意义(P<0.05),B组患者治疗总有效率(97.06%)明显高于A组患者的(79.41%),差异有统计学意义(P<0.05),两组患者在不良反应发生率差异无统计学意义(P>0.05)。结论:椎旁神经阻滞联合药物治疗老年人肺癌开胸术后肋间神经痛临床疗效确切,安全高效,明显改善患者的疼痛程度和睡眠质量,明显改善患者的预后。Objective： To investigate the clinical efficacy of elderly lung cancer patients with intercostal neuralgia after thoracotomy by paravertebral nerve block combined nimesulide tablet. Methods： The clinical data of sixty-eight elderly lung cancer patients who were treated in our hospital from August 2010 to August 2012 were collected, then patients were divided into A group and B group by using a random number table. Patients in A group was given paravertebral nerve block, but patients in B group was given par- avertebral nerve block combined nimesulide tablet. The other measures were the same. The anesthesia effect and safety of them was evaluated. Results： Visual analogue scale and sleep quality score in patients was higher at the be^nning than that at the points of one week,two weeks and three weeks （P〈0.05）, visual analogue scale and sleep quality score in patients in B group was lower than that in A group at the points of three weeks（P〈0.05）, the anesthesia effect was lower in B group than that in A group （97.06% vs 79.41%, P〈0.05）, the incidence of adverse reaction was not different in two groups （P〈0.05）. Concluaion： The the clinical efficacy study on elderly lung cancer patients with intercostal neuralgia after thoracotomy by paravertebral nerve block combined drug therapy is good and safe,with high efficiency, less adverse reactions. It obviously improves patients＇ experience of pain and sleep quality in order to obviously improve the prognosis of patients.

关 键 词：椎旁神经阻滞 尼美舒利 肺癌开胸术 肋间神经痛 

分 类 号：R734.2[医药卫生—肿瘤] R614[医药卫生—临床医学]