老年脑梗死继发癫痫患者血清D-二聚体,IL-1β和TNF-α水平与脑电图严重程度的关系  

Relationship among Serum D-dimer, IL-1β and TNF-alpha and EEG Severity in Elderly Patients with Cerebral Infarction Combined with Epilepsy

作　　者：毕明慧[1] 俞正霞[1] 龚青[1] 何悦[1] 赵轶[2] 

机构地区：[1]上海市徐汇区中心医院老年病科,上海200031 [2]上海市徐汇区中心医院神经内科,上海200031

出　　处：《现代生物医学进展》2013年第11期2110-2112,2116,共4页Progress in Modern Biomedicine

摘　　要：目的:观察D-二聚体,IL-1β和TNF-α水平在老年脑梗死继发癫痫患者中的意义。方法:选择2009年1月-2012年8月我院就诊的脑梗死患者110例,根据有无继发癫痫分为脑梗死癫痫组(65例)和单纯脑梗死组(45例)。选取同期健康体检者20例为健康对照组。分别检测各组血清D-二聚体,IL-1β和TNF-α水平。结果:D-二聚体,IL-1β和TNF-α水平脑梗死癫痫组和单纯脑梗死组较正常对照组明显提高(P<0.01),而脑梗死癫痫组较单纯脑梗死组提高更为明显(P<0.01)。65例脑梗死伴癫痫的患者中,正常范围者4例,轻度异常10例,中度异常30例,重度异常21例。而脑梗死癫痫组的D-二聚体,IL-1β和TNF-α水平随着脑电图严重程度增加而水平逐渐增高(P<0.01)。结论:D-二聚体,IL-1β和TNF-α可能参与了脑梗死继发癫痫的发病过程,是反映癫痫发病的严重程度的重要指标。Objective： To observe the significance of D-dimer,IL-1β and TNF-alpha in elderly patients with cerebral infarction combined with epilepsy.Methods： 110 elderly patients with cerebral infarction combined with epilepsy,from January 2009 to August 2012,according to epilepsy,were divided into cerebral infarction with epilepsy group（65 cases） and simple cerebral infarction group（45 cases）.20 healthy persons in the same period were selected as healthy control group.Of 65 patients with cerebral infarction combined with epilepsy,4 was in the normal range,10 was in the mildly abnormal,30 was in the moderate abnormality,21 was in the severe abnormal.The serum D-dimer,IL-1β and TNF-α were detected in each groups.Results： The levels of D-dimer,IL-1β and TNF-α were increased significantly in the cerebral infarction with epilepsy group and simple cerebral infarction group than those in the healthy control group（P〈0.01）,and cerebral infarction in the epilepsy group than a simple cerebral infarction group to improve more significantly（P〈0.01）.The levels of D-dimer,IL-1β and TNF-α levels in the cerebral infarction with epilepsy group were gradually increased as the EEG severity were increased（P〈0.01）.Conclusion： The D-dimer,IL-1β and TNF-α may be involved in the pathogenesis of cerebral infarction with epilepsy,it is an important indicator of severity in elderly patients with cerebral infarction combined with epilepsy.

关 键 词：脑梗死 癫痫 D-二聚体 IL-1Β TNF-Α 

分 类 号：R743[医药卫生—神经病学与精神病学]