IGF-Ⅰ调节血脂异常在结直肠腺瘤发生和恶变中的作用  

The Effect of Dyslipidemia Regulated by IGF-Ⅰ on the Development and Malignant Transformation of Colorectal Adenomas

作　　者：秦文[1] 庄丽维[1] 李滨[1] 凌霄华[1] 王立国[1] 于欣[1] 

机构地区：[1]哈尔滨医科大学附属第四医院,黑龙江哈尔滨150001

出　　处：《现代生物医学进展》2013年第11期2168-2171,共4页Progress in Modern Biomedicine

摘　　要：大量的研究表明脂类代谢异常与结直肠腺瘤的发生、复发及癌变有必然的联系,是结直肠腺瘤发生的独立风险因子。胰岛素样生长因子-Ⅰ(insulin-like growth factor-Ⅰ,IGF-Ⅰ)作为一种重要的循环内分泌多肽,参与了调节脂代谢、细胞的分化和成熟的过程,且已有众多研究证实IGF-Ⅰ在结直肠癌组织中高表达,在结直肠癌的发生及结直肠腺瘤向癌的发展过程中起重要作用。因此,本文将就IGF-Ⅰ调节血脂代谢在结直肠腺瘤发生和恶变中的作用作一综述。A number of studies have shown that the lipid metabolic abnormalities play an important role in the development,recurrence and malignant transformation of colorectal adenoma.It is an independent risk factor of malignancy of colorectal adenoma.IGF-Ⅰis a kind of important circulation endocrine peptide and participates in the regulation of lipid metabolism,cell differentiation and mature.A lot of study have confirmed that the overexpression of IGF-Ⅰ is correlated with the development and malignant transformation of colorectal adenomas.This article is aimed to review the effect of lipids metabolism regulated by IGF-Ⅰ on the development and malignant transformation of colorectal adenomas.

关 键 词：结直肠腺瘤 血脂异常 胰岛素样生长因子-Ⅰ 恶变 

分 类 号：R735.3[医药卫生—肿瘤]