TNF-α和IFN-γ对肝纤维化发病学意义的探讨  

The pathogensis significance of serum TNF-αand IFN-γin liver fibrosis

作　　者：王子强[1] 徐章[1] 李毅[1] 张兵[1] 胡阳黔[1] 黄晓东[1] 张洁琴[1] 

机构地区：[1]湖北省十堰市东风汽车公司中心医院消化科,十堰442008

出　　处：《胃肠病学和肝病学杂志》2000年第3期190-191,共2页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的探讨ＴＮＦ－α和ＩＦＮ－γ在肝纤维化发病中的学意义。方法采用双抗体夹心ＥＬＩＳＡ法、放免法测定１１５例肝病、２０例健康成人血清ＴＮＦ－α、ＩＦＮ－γ及ＬＮ、ＰＣＩ、ＫⅢ水平。结果肝病组ＴＮＦ－ａ、ＩＦＮ－γ明显高于正常对照组（Ｐ＜０．０１）．而ＬＮ、ＰＣⅢ同步升高，ＰＣⅠ在急性肝炎、慢性肝炎（中重型）亦明显增高（Ｐ＜０．０１）。结论本组资料提示ＴＮＦ－α、ＩＦＮ－γ等细胞因子对肝纤维化具有调控作用。Aim To study the pathogenesis significance of serum tumor necrosis factor a(TNF - ) and interferon- (IFN-γ) in liver fibrosis.Mothods The serum levels of TNF-α , IFN-γ, laminin(LN), type I procollagen(PCⅠ) and typeⅢ procollagen (PCⅢ ) were measured by means of double antibody sandwich ELISA and RIA in 115 patients with varied liver diseases and 20 normal controls . Results The TNF-α and IFN-γ concentration in pationts with acute hepatitis, chronic hepatitis or liver cirrhosis were elevated compared with the normal controls (P < 0. 01, respectively). At the same time, the serum levels of LN and PCⅢ were elevated too. The PCⅠ concentration were higher in patients with acute hepatitis or chronic hepatitis (moderate to grave type) compared with nomal controls(P < 0.01, seperately). Conclution The cell factors such as TNF-α and IFN-γ are important mediatiors in fibrosis regulation.

关 键 词：TNF-Α IFN-Γ 肝纤维化 

分 类 号：R575.202[医药卫生—消化系统]