番茄红素的抗肿瘤作用及其机制  

Anti-tumor activity and its mechanism of lycopene

作　　者：韩静[1] 凌志强[1] 

机构地区：[1]浙江省肿瘤医院浙江省肿瘤研究所,杭州310022

出　　处：《国际肿瘤学杂志》2013年第4期264-267,共4页Journal of International Oncology

基　　金：“重大新药创制”科技重大专项（2009ZXJ09001-034）;浙江省中医药科学研究基金计划（2012ZB018）

摘　　要：番茄红素是一种重要的天然类胡萝卜素，广泛存在于人体组织和血液中，具有预防多种癌症、抗老化等作用。它可以通过抑制口腔癌细胞增殖、增强细胞间连接通讯来预防口腔癌的发生，通过降低多种基质金属蛋白酶（MMP）的活性来抑制大肠癌的发展，使抗转移基因如nm23-H1等的表达量增加而发挥抗转移作用。Lycopene is an important natural carotenoid, and is widely found in human tissues and blood, with the prevention of many types of cancer, anti-aging effect. It can inhibit the proliferation of cancer ceils of oral malignancy, and increasing of gap-junction communication between cells to prevent oral cancer, and also can inhibit the development of colorectal cancer by reducing the activity of matrix metalloproteinase. It plays the role of anti-metastasis through enhancing the expression of anti-metastatic gene nm23-H1.

关 键 词：肿瘤 番茄红素 

分 类 号：R285.5[医药卫生—中药学]