18F—FDGPET—CT在诊断淋巴瘤相关噬血细胞综合征中的应用  

Diagnostic value of 18F-FDG PET-CT in lymphoma associated hemophagocytic syndrome

作　　者：李硕[1] 王昭[1] 王旖旎[1] 张嘉[1] 闫丽娟[1] 卫青[1] 汤然[1] 

机构地区：[1]首都医科大学附属北京友谊医院血液科,100050

出　　处：《白血病．淋巴瘤》2013年第4期209-211,共3页Journal of Leukemia & Lymphoma

基　　金：国家自然科学基金（81270653）;首都医学发展科研基金（2009-1032）;北京市科技计划首都临床特色应用研究（D101100050010005）;中华医学会临床医学科研专项资金（11010020246）;北京友谊医院科研启动基金（YYQDKT2011-6）

摘　　要：目的探讨18F—FDGPET—CT在淋巴瘤相关噬血细胞综合征（LAHS）诊断中的应用。方法回顾性分析30例噬血细胞综合征（HPS）患者资料，均行18F-FDGPET-CT检测，与最终经病理结果进行比较，计算18F—FDGPET—CT诊断LAHS的敏感度、特异度、阳性预测值和阴性预测值，并分析LAHS在PET-CT中的显像特点。结果30例HPS患者中18F—FDGPET—CT诊断LAI-IS的灵敏度为85．71％（12／14），特异度为93．75％（15／16），阳性预测值为92.31％（12／13），阴性预测值为88．24％（15／7）。18F-FDGPET—CT对于T、B细胞LAHS的检出率差异无统计学意义（P=0．066）。LAHS浅表淋巴结常以锁骨上淋巴结累及为主。而在深部组织器官中，脾为最常累及部位，其次为肝、腹腔腹膜后淋巴结及骨髓。结论在HPS确诊情况下，18F-FDGPET—CT检出LAHS具有较高的敏感度和特异度，可为LAHS的诊断、指导治疗提供更多有价值的信息。Objective To explore the diagnostic value of 18F-FDG PET-CT in lymphoma associated hemophagoeytic syndrome （HSP）. Methods Retrospective analysis of 30 patients with HPS who underwent 18F-FDG PET-CT detection, and was also compared to pathologically confirmed lymphoma associated HPS to evaluate its diagnostic sensitivity, specificity, positive predictive value and negative predictive value, and to analyze the characteristics of PET-CT imaging in lymphoma associated HPS. Results In the 30 patients, the sensitivity, specificity, positive predictive value and negative predictive value in detecting lymphoma associated HPS by 18F-FDG PET-CT were 85.71% （12/14）, 93.75 % （15/16）, 92.31% （12/13） and 88.24 % （15/17）, respectively. The sensitivities of PET-CT between T-cell and B-cell lymphoma related HPS had no significant difference （P = 0.066）. In superficial lymph nodes, supraclavicular lymph nodes were the most commonly involved. In deeper tissues and organs, spleen was the most commonly involved site, followed by liver, abdominal retroperitoneal lymph nodes and bone marrow. Conclusion 18F-FDG PET-CT has a high sensitivity and specificity in the detection of lymphoma associated HPS, and may provide valuable information for diagnosis and treatment.

关 键 词：18F-FDG PET-CT 淋巴瘤 噬血细胞综合征 

分 类 号：R733[医药卫生—肿瘤] R5[医药卫生—临床医学]