Shiga toxin-producing Escherichia coli O104:H4: An emerging 0important pathogen in food safety  

Shiga toxin-producing Escherichia coli O104:H4: An emerging important pathogen in food safety

作　　者：CUI YuJun LI DongFang YANG RuiFu 

机构地区：[1]State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology [2]BGI-Shenzhen

出　　处：《Chinese Science Bulletin》2013年第14期1625-1631,共7页

基　　金：supported by the National Basic Research Program of China(2009CB522600);Shenzhen Biological Industry Development Special Foundation-Basic Research Key Projects (JC201005250088A)

摘　　要：In 2011, Shiga toxin-producing Escherichia coli O104 : H4 resulted in a large outbreak of bloody diarrhea and hemolytic uremic syndrome (HUS) in Germany and 15 other countries in Europe and North America. This event raised a serious public health crisis and caused more than two billion US dollars in economic losses. In this review, we describe the classification of E. coli, the Germany outbreak, and the characteristics and epidemical source-tracing of the causative agent. We also discuss the genomics analysis of the outbreak organism and propose an open-source genomics analysis as a new strategy in combating the emerging infectious diseases.In 2011, Shiga toxin-producing Escherichia coli O104：H4 resulted in a large outbreak of bloody diarrhea and hemolytic uremic syn- drome （HUS） in Germany and 15 other countries in Europe and North America. This event raised a serious public health crisis and caused more than two billion US dollars in economic losses. In this review, we describe the classification of E. coli, the Germany outbreak, and the characteristics and epidemical source-tracing of the causative agent. We also discuss the genomics analysis of the outbreak organism and propose an open-source genomics analysis as a new strategy in combating the emerging infectious diseases.

关 键 词：大肠杆菌 志贺毒素 病原体 食品安全 大肠埃希菌 公共卫生 经济损失 流行病学 

分 类 号：R155.5[医药卫生—营养与食品卫生学]