Re-mention of an old neurodegenerative disease:Alzheimer's disease  

作　　者：ZHANG Peng ADAMS Ursula YUAN ZengQiang 

机构地区：[1]State Key Laboratory of Brain and Cognitive Sciences,Institute of Biophysics,Chinese Academy of Sciences [2]Biological Sciences,The University of Chicago

出　　处：《Chinese Science Bulletin》2013年第15期1731-1736,共6页

基　　金：supported in part by the National Natural Science Foundation of China (81030025 and 81125010);the National Basic Research Program of China (2009CB918704)

摘　　要：Alzheimer's disease(AD),the most common form of neuropsychiatric disorder,is characterized by neuronal degeneration and inexorably progressing dementia,especially in the elderly population.With a rapidly aging population in both developed and developing countries,AD has emerged as one of the largest growing problems worldwide.Current drugs improve the symptoms of AD,but do not have any profound intervention to delay its onset.Thus,understanding the molecular mechanisms underlying the genes tied to AD will be crucial to the development of therapeutic targets.This review will summarize the aetiology,pathology,and the evidence for the genetic components in AD,discuss the proposed amyloid cascade and the following tau hyperphosphorylation hypothesises,oxidative stress mediated neuronal cell death,as well as the function of Retromer complex during the developing of AD.Our laboratory's current research progress and the challenges that still remained will be also highlighted.Alzheimer＇s disease （AD）, the most common form of neuropsychiatric disorder, is characterized by neuronal degeneration and inexorably progressing dementia, especially in the elderly population. With a rapidly aging population in both developed and de- veloping countries, AD has emerged as one of the largest growing problems worldwide. Current drugs improve the symptoms of AD, but do not have any profound intervention to delay its onset. Thus, understanding the molecular mechanisms underlying the genes tied to AD will be crucial to the development of therapeutic targets. This review will summarize the aetiology, pathology, and the evidence for the genetic components in AD, discuss the proposed amyloid cascade and the following tau hyperphosphor- ylation hypothesises, oxidative stress mediated neuronal cell death, as well as the function of Retromer complex during the de- veloping of AD. Our laboratory＇s current research progress and the challenges that still remained will be also highlighted.

关 键 词：神经退行性疾病 阿尔茨海默氏症 阿尔茨海默氏病 Complex 老年痴呆症 神经细胞死亡 淀粉样蛋白 精神障碍 

分 类 号：R749.16[医药卫生—神经病学与精神病学]