基于调强放疗的鼻咽癌临床分型研究  被引量:1

Study on clinical typing of nasopharyngeal carcinoma in patients treated by intensity-modulated radiotherapy

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作  者:张冉[1] 吴君心[1] 徐鹭英[1] 林少俊[1] 杨凌[1] 陈传本[1] 潘建基[1] 

机构地区:[1]福建医科大学省立临床医学院福建省肿瘤医院放疗科,福州350014

出  处:《中华放射肿瘤学杂志》2013年第3期217-219,共3页Chinese Journal of Radiation Oncology

基  金:福建省临床重点专科建设项目(2012)

摘  要:目的探讨调强放疗时代鼻咽癌患者临床分型的现状。方法分析2003--2006年本院连续收治的初治、无远处转移、调强放疗的鼻咽癌333例,根据预后情况进行临床分型。分型定义为I型:放射敏感不易转移型;Ⅱ型:放射抗拒不易转移型;Ⅲ型:放射敏感易转移型;IV型:放射抗拒易转移型。结果全组I、Ⅱ、Ⅲ、Ⅳ型所占比例分别为70.0%(233例)、12.9%(43例)、16.5%(55例)、0.6%(2例);I+Ⅱ期(57例)分别为86%(49例)、11%(6例)、4%(2例)、0%(0例),Ⅲ+Ⅳ期(276例)分别为66.7%(184例)、13.4%(37例)、19.2%(53例)、0.7%(2例)(P=0.007);无化疗者(69例)分别为80%(55例)、12%(8例)、9%(6例)、0%(0例),新辅助加同期化疗者(218例)分别为68.8%(150例)、13.8%(30例)、16.5%(36例)、0.9%(2例),新辅助加辅助化疗者(46例)分别为61%(28例)、11%(5例)、28%(13例)、0%(0例)。结论I型在早、晚期均占最大比例,Ⅳ型均占最小比例;早期中Ⅱ型〉皿型,晚期中Ⅲ型〉Ⅱ型。与常规放疗资料相比I型比例提高,其他型均减少。Objective To investigate the clinical typing of nasopharyngeal carcinoma in patients treated by intensity-modulated radiation therapy (IMRT). Methods A retrospective analysis was performed on 333 patients with nasopharyngeal carcinoma who were initially treated in our hospital from 2003 to 2006 ; they had no distant metastasis and received IMRT. These patients were divided into 4 clinical types according to their prognosis:type I (without local-regional recurrence and without distant metastasis), type Ⅱ (with local-regional recurrence and without distant metastasis), type Ⅲ (without local-regional recurrence and with distant metastasis), and type IV (with local-regional recurrence and with distant metastasis ). Results Of all the patients, 70.0% (233) were of type I ,12.9% (43) of type 11, 16. 5% (55) of type Ⅲ, and 0. 6% (2) of type IV. Of 57 patients with stage I --Ⅱ nasopharyngeal carcinoma, 86% (49) were of type I , 11% (6) of type Ⅱ,4% (2) of type Ⅲ, and 0% (0) of type IV, and of 276 patients with stage Ⅲ--IV nasopharyngeal carcinoma, 66. 7% (184) were of type Ⅰ , 13.4% (37) of type Ⅱ , 19. 2% (53) of type Ⅲ, and 0. 7% (2) of type IV, with significant differences between the two patient groups (P = 0. 007). Of the 69 patients who received IMRT alone, 80% (55) were of type I , 12% (8) of type Ⅱ, 9%(6) of type Ⅲ, and 0% (0) of type IV; of the 218 patients who received IMRT combined with neoadjuvant plus concurrent chemotherapy, 68.8% (150) were of type I ,13.8% (30) of type Ⅱ , 16. 5% (36) of type Ⅲ, and 0.9% (2) of type IV; of the 46 patients who received IMRT combined with neoadjuvant plus adjuvant chemotherapy, 61% (28) were of type I, 11% (5) of type Ⅱ, 28% (13) of type Ⅲ, and 0% (0) of type IV. Condusions In patients with early and advanced nasopharyngeal carcinoma, type I is the most common, and type IV is the least common; type Ⅱ is more frequent tha

关 键 词:鼻咽肿瘤 调强放射疗法 临床分型 

分 类 号:R739.63[医药卫生—肿瘤]

 

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